Drug Detail


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Drug Name Alvocidib
Trade Name
Synonyms flavopiridol|HMR 1275|L-868275|DSP-2033
Drug Descriptions

Alvocidib (flavopiridol) is an inhibitor of CDK1, CDK2, CDK4, CDK6, CDK7, and CDK9, which may induce cell cycle arrest and apoptosis in cancer cells (PMID: 12165651, PMID: 8674031, PMID: 24470357).

DrugClasses CDK Inhibitor (Pan) 3 CDK1 Inhibitor 13 CDK2 Inhibitor 30 CDK4 Inhibitor 17 CDK6 Inhibitor 6 CDK7 Inhibitor 16 CDK9 Inhibitor 21
CAS Registry Number 131740-09-5


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Therapy Name Drugs Efficacy Evidence Clinical Trials
Aldoxorubicin + Alvocidib Aldoxorubicin Alvocidib 0 0
Alvocidib Alvocidib 2 2
Alvocidib + BAY-293 Alvocidib BAY-293 0 0
Alvocidib + Crizotinib Alvocidib Crizotinib 1 0
Alvocidib + Cytarabine Alvocidib Cytarabine 0 1
Alvocidib + Cytarabine + Daunorubicin Alvocidib Cytarabine Daunorubicin 0 1
Alvocidib + Decitabine + Venetoclax Alvocidib Decitabine Venetoclax 0 1
Alvocidib + Doxorubicin Alvocidib Doxorubicin 0 0
Alvocidib + Palbociclib Alvocidib Palbociclib 0 0
Alvocidib + Seliciclib Alvocidib Seliciclib 0 0
Alvocidib + Sorafenib Alvocidib Sorafenib 0 0
Alvocidib + Venetoclax Alvocidib Venetoclax 0 1

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