Therapy Detail

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Therapy Name Alvocidib
Synonyms
Therapy Description

Alvocidib (flavopiridol) is an inhibitor of CDK1, CDK2, CDK4, CDK6, CDK7, and CDK9, which may induce cell cycle arrest and apoptosis in cancer cells (PMID: 12165651, PMID: 8674031, PMID: 24470357).

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Drug Name Trade Name Synonyms Drug Classes Drug Description
Alvocidib flavopiridol|HMR 1275|L-868275|DSP-2033 CDK Inhibitor (Pan) 3 CDK1 Inhibitor 13 CDK2 Inhibitor 19 CDK4 Inhibitor 12 CDK6 Inhibitor 3 CDK7 Inhibitor 13 CDK9 Inhibitor 16 Alvocidib (flavopiridol) is an inhibitor of CDK1, CDK2, CDK4, CDK6, CDK7, and CDK9, which may induce cell cycle arrest and apoptosis in cancer cells (PMID: 12165651, PMID: 8674031, PMID: 24470357).

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
CDKN2A loss melanoma sensitive Alvocidib Preclinical Actionable In a preclinical study, melanoma cell lines with CDKN2A loss demonstrated a greater sensitivity to Alvocidib (flavopiridol) as compared to melanoma cell lines positive for CDKN2A (PMID: 12777976). 12777976
EML4 - ALK lung adenocarcinoma sensitive Alvocidib Preclinical - Cell line xenograft Actionable In a preclinical study, Alvocidib (flavopiridol) treatment induced cell cycle arrest and apoptosis, reduced viability, and inhibited proliferation of EML4-ALK harboring parental lung adenocarcinoma, and Xalkori (crizotinib), Zykadia (ceritinib), and Alecensa (alectinib)-resistant cells in culture, and reduced tumor growth in Xalkori (crizotinib) and Alecensa (alectinib)-resistant cell line xenograft models (PMID: 32558295). 32558295
SMARCB1 negative rhabdoid cancer sensitive Alvocidib Preclinical - Cell line xenograft Actionable In a preclinical study, Alvocidib (flavopiridol) induced cell-cycle arrest and inhibited growth of human rhabdoid tumor cell lines with SMARCB1 biallelic deficiency in culture and inhibted tumor growth in SMARCB1-deficient cell line xenograft models (PMID: 18223228). 18223228
Unknown unknown melanoma no benefit Alvocidib Phase II Actionable In a Phase II trial, Alvocidib (flavopiridol) treatment resulted in stable disease in 44% (7/16) of patients with melanoma, but no objective response (PMID: 15122079). 15122079
Unknown unknown chordoma not applicable Alvocidib Preclinical - Cell culture Actionable In a preclinical study, Alvocidib (flavopiridol) treatment reduced viability of chordoma cells in culture (PMID: 30664779). 30664779

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Clinical Trial Phase Therapies Title Recruitment Status
NCT03969420 Phase II Alvocidib + Cytarabine Alvocidib Study of Alvocidib in Patients With Relapsed/Refractory AML Following Treatment With Venetoclax Combination Therapy Recruiting
NCT02520011 Phase II Alvocidib Cytarabine + Mitoxantrone Alvocidib Biomarker-driven Phase 2 AML Study Terminated


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