Drug Detail


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Drug Name AZD4547
Trade Name
Synonyms AZD-4547
Drug Descriptions

AZD4547 selectively binds and inhibits FGFR1, 2, and 3, which may result in the inhibition of FGFR-mediated signal transduction pathways and inhibition of tumor cell proliferation (PMID: 22369928, PMID: 30115694, PMID: 32463741), and has demonstrated inhibitory effects on NTRK signaling (PMID: 34790577).

DrugClasses FGFR1 Inhibitor 28 FGFR2 Inhibitor 23 FGFR3 Inhibitor 19
CAS Registry Number 1035270-39-3
NCIT ID C88272


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Therapy Name Drugs Efficacy Evidence Clinical Trials
ABT-737 + AZD4547 ABT-737 AZD4547 3 0
Alpelisib + AZD4547 + Osimertinib AZD4547 Alpelisib Osimertinib 0 0
Anastrozole + AZD4547 AZD4547 Anastrozole 0 0
AZD4547 AZD4547 147 2
AZD4547 + AZD8055 AZD4547 AZD8055 2 0
AZD4547 + Buparlisib AZD4547 Buparlisib 3 0
AZD4547 + Capivasertib AZD4547 Capivasertib 0 0
AZD4547 + Cisplatin + Gemcitabine AZD4547 Cisplatin Gemcitabine 0 0
AZD4547 + Crizotinib AZD4547 Crizotinib 0 0
AZD4547 + Durvalumab AZD4547 Durvalumab 0 1
AZD4547 + Fulvestrant AZD4547 Fulvestrant 1 0
AZD4547 + Gefitinib AZD4547 Gefitinib 0 0
AZD4547 + Lapatinib AZD4547 Lapatinib 0 0
AZD4547 + Letrozole AZD4547 Letrozole 0 0
AZD4547 + Osimertinib AZD4547 Osimertinib 0 0
AZD4547 + Pictilisib AZD4547 Pictilisib 1 0
AZD4547 + Sapanisertib AZD4547 Sapanisertib 0 0
AZD4547 + Sirolimus AZD4547 Sirolimus 2 0
AZD4547 + Trametinib AZD4547 Trametinib 0 0
AZD4547 + Vistusertib AZD4547 Vistusertib 3 0

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