Drug Detail


Missing content? – Request curation!

Request curation for specific Genes, variants, or PubMed publications.

Have questions, comments or suggestions? - Let us know!

Email us at : ckbsupport@jax.org

Drug Name AZD4547
Trade Name
Synonyms AZD-4547
Drug Descriptions

AZD4547 selectively binds and inhibits FGFR1, 2, and 3, which may result in the inhibition of FGFR-mediated signal transduction pathways and inhibition of tumor cell proliferation (PMID: 22369928, PMID: 30115694, PMID: 32463741), and has demonstrated inhibitory effects on NTRK signaling (PMID: 34790577).

DrugClasses FGFR1 Inhibitor 24 FGFR2 Inhibitor 18 FGFR3 Inhibitor 13
CAS Registry Number 1035270-39-3
NCIT ID C88272


  • Case insensitive filtering will display rows where any text in any cell matches the filter term
  • Simple literal full or partial string matches
  • Separate multiple filter terms with a spaces, order doesn't matter (a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page, filtering has no impact on query parameters
  • Use quotes to match a longer phrase which contains spaces "mtor c1483f"


  • Generally, the default sort order for tables is set to be first column ascending, however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column, be sure to set ascending or descending order for a given column, before moving on to the next column.

Therapy Name Drugs Efficacy Evidence Clinical Trials
ABT-737 + AZD4547 ABT-737 AZD4547 3 0
Anastrozole + AZD4547 AZD4547 Anastrozole 0 0
AZD4547 AZD4547 161 3
AZD4547 + AZD8055 AZD4547 AZD8055 2 0
AZD4547 + Buparlisib AZD4547 Buparlisib 4 0
AZD4547 + Capivasertib AZD4547 Capivasertib 0 0
AZD4547 + Cisplatin + Gemcitabine AZD4547 Cisplatin Gemcitabine 0 0
AZD4547 + Crizotinib AZD4547 Crizotinib 0 0
AZD4547 + Durvalumab AZD4547 Durvalumab 0 1
AZD4547 + Fulvestrant AZD4547 Fulvestrant 1 0
AZD4547 + Gefitinib AZD4547 Gefitinib 0 0
AZD4547 + Lapatinib AZD4547 Lapatinib 0 0
AZD4547 + Letrozole AZD4547 Letrozole 0 0
AZD4547 + Pictilisib AZD4547 Pictilisib 1 0
AZD4547 + Sapanisertib AZD4547 Sapanisertib 2 0
AZD4547 + Sirolimus AZD4547 Sirolimus 2 0
AZD4547 + Trametinib AZD4547 Trametinib 0 0
AZD4547 + Vistusertib AZD4547 Vistusertib 3 0

Additional content available in CKB BOOST