Therapy Detail

Therapy Name AGS-003 + Sunitinib
Therapy Description

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Drug Name Trade Name Synonyms Drug Classes Drug Description
AGS-003 AGS-003 is an immunotherapy that comprises autologous dendritic cells transfected with patient tumor-derived RNA and CD40LG (CD40L) RNA, which may result in induction of an anti-tumor immune response (PMID: 25901286).
Sunitinib Sutent SU011248 CSF1R Inhibitor 22 FLT3 Inhibitor 50 KIT Inhibitor 48 PDGFR Inhibitor (Pan) 27 RET Inhibitor 36 VEGFR2 Inhibitor 34 Sutent (sunitinib) inhibits KDR (VEGFR2), PDGFR, c-KIT, FLT3, RET, and CSF1R, thereby inhibiting angiogenesis and cell proliferation (PMID: 25085632). Sutent (sunitinib) is approved for neuroendocrine tumors of the pancreas, advanced renal cell carcinoma, and GIST (FDA.gov).
Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
Unknown unknown renal cell carcinoma not applicable AGS-003 + Sunitinib Phase II Actionable In a Phase II clinical trial, treatment with the combination of AGS-003 and Sutent (sunitinib) resulted in clinical benefit in 62% (13/21) of patients with advanced renal cell carcinoma, with 9 partial responses and 4 patients achieving stable disease, a median overall survival of 30.2 months, and median progression-free survival if 11.2 months (PMID: 25901286). 25901286
Clinical Trial Phase Therapies Title Recruitment Status