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PLX9486 is a Kit inhibitor with selective activity against primary (exon 9 and 11) and secondary (exon 17 and 18) Kit mutations, which may lead to growth inhibition in tumor cells expressing mutant c-Kit (Journal of Clinical Oncology 36, no. 15_suppl (May 20 2018) 11509-11509, PMID: 30523507).
|DrugClasses||KIT Inhibitor 51|
|CAS Registry Number||NA|
|Therapy Name||Drugs||Efficacy Evidence||Clinical Trials|
|Pexidartinib + PLX9486||PLX9486 Pexidartinib||3||1|
|PLX9486 + Sunitinib||PLX9486 Sunitinib||0||1|