Drug Detail


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Drug Name PLX9486
Trade Name
Synonyms PLX-9486|PLX 9486|Bezuclastinib|CGT-9486|CGT9486|CGT 9486
Drug Descriptions

PLX9486 is a Kit inhibitor with selective activity against primary (exon 9 and 11) and secondary (exon 17 and 18) Kit mutations, which may lead to growth inhibition in tumor cells expressing mutant c-Kit (Journal of Clinical Oncology 36, no. 15_suppl (May 20 2018) 11509-11509, PMID: 30523507).

DrugClasses KIT Inhibitor 57
CAS Registry Number NA
NCIT ID C121647


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Therapy Name Drugs Efficacy Evidence Clinical Trials
Pexidartinib + PLX9486 PLX9486 Pexidartinib 2 1
PLX9486 PLX9486 9 4
PLX9486 + Sunitinib PLX9486 Sunitinib 0 3

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