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| Drug Name | M8891 |
| Trade Name | |
| Synonyms | CS-0109402 |
| Drug Descriptions |
M8891 is an inhibitor of methionine aminopeptidase 2 (MetAP2), which results in cleavage of the aminoterminal methionine residue from an early forming protein, thereby disrupting protein synthesis and potentially result in reduced proliferation of endothelial cells (PMID: 31725285). |
| DrugClasses | |
| CAS Registry Number | NA |
| NCIT ID | C142831 |
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| Therapy Name | Drugs | Efficacy Evidence | Clinical Trials |
|---|---|---|---|
| Axitinib + M8891 | Axitinib M8891 | 1 | 0 |
| Cabozantinib + M8891 | Cabozantinib M8891 | 1 | 0 |
| M8891 | M8891 | 1 | 1 |
| M8891 + Sunitinib | M8891 Sunitinib | 1 | 0 |
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