Drug Detail


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Drug Name M8891
Trade Name
Synonyms CS-0109402
Drug Descriptions

M8891 is an inhibitor of methionine aminopeptidase 2 (MetAP2), which results in cleavage of the aminoterminal methionine residue from an early forming protein, thereby disrupting protein synthesis and potentially result in reduced proliferation of endothelial cells (PMID: 31725285).

CAS Registry Number NA
NCIT ID C142831


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Therapy Name Drugs Efficacy Evidence Clinical Trials
Axitinib + M8891 Axitinib M8891 1 0
Cabozantinib + M8891 Cabozantinib M8891 1 0
M8891 M8891 1 1
M8891 + Sunitinib M8891 Sunitinib 1 0

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