Drug Detail


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Drug Name HDM201
Trade Name
Synonyms Siremadlin|HDM-201|NVP-HDM201
Drug Descriptions

Siremadlin (HDM201) binds to MDM2 and inhibits its interaction with p53, which prevents p53 degradation and potentially leads to restoration of p53 signaling and increased tumor cell death (PMID: 30899200, PMID: 27542305).

DrugClasses MDM2 Inhibitor 19


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Therapy Name Drugs Efficacy Evidence Clinical Trials
HDM201 HDM201 0 2
HDM201 + IDE196 HDM201 IDE196 0 1
HDM201 + Ribociclib HDM201 Ribociclib 0 1
HDM201 + Sabatolimab HDM201 Sabatolimab 0 1
HDM201 + Venetoclax HDM201 Venetoclax 0 1

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