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Drug Name Evofosfamide
Trade Name
Synonyms TH-302
Drug Descriptions

Evofosfamide (TH-302) is a hypoxia-activated prodrug that releases a DNA-alkylating dibromo isophosphoramide mustard moiety within hypoxic regions of tumors, potentially providing antineoplastic activity with reduced systemic toxicity (NCI Drug Dictionary).

DrugClasses Chemotherapy - Alkylating 14

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Therapy Name Drugs Efficacy Evidence Clinical Trials
Bevacizumab + Dexamethasone + Evofosfamide Bevacizumab Dexamethasone Evofosfamide 1 0
Bevacizumab + Evofosfamide Bevacizumab Evofosfamide 0 2
Dexamethasone + Evofosfamide Dexamethasone Evofosfamide 1 0
Evofosfamide Evofosfamide 1 2
Evofosfamide + Ipilimumab Evofosfamide Ipilimumab 0 1
Evofosfamide + Pazopanib Evofosfamide Pazopanib 0 1
Evofosfamide + Sorafenib Evofosfamide Sorafenib 0 1


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