Drug Detail


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Drug Name Nab-rapamycin
Trade Name Fyarro
Synonyms ABI-009|nab-sirolimus
Drug Descriptions

Fyarro (nab-rapamycin) is nanoparticle albumin-bound rapamycin and inhibitor of mTOR that has immunosuppressant and anti-tumor activities (PMID: 24089446). Fyarro (nab-rapamycin) is FDA approved for use in patients with locally advanced unresectable or metastatic malignant perivascular epithelioid cell tumor (FDA.gov).

DrugClasses mTORC1 Inhibitor 9
CAS Registry Number NA
NCIT ID C74065


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Therapy Name Drugs Efficacy Evidence Clinical Trials
Bevacizumab + Fluorouracil + Leucovorin + Nab-rapamycin + Oxaliplatin Bevacizumab Fluorouracil Leucovorin Nab-rapamycin Oxaliplatin 0 1
Bevacizumab + Nab-rapamycin Bevacizumab Nab-rapamycin 0 1
Dasatinib + Irinotecan + Nab-rapamycin + Temozolomide Dasatinib Irinotecan Nab-rapamycin Temozolomide 0 0
Dexamethasone + Nab-rapamycin + Pomalidomide Dexamethasone Nab-rapamycin Pomalidomide 0 1
Irinotecan + Nab-rapamycin + Temozolomide Irinotecan Nab-rapamycin Temozolomide 0 1
Lomustine + Nab-rapamycin Lomustine Nab-rapamycin 0 1
Nab-rapamycin Nab-rapamycin 0 5
Nab-rapamycin + Nivolumab Nab-rapamycin Nivolumab 0 1
Nab-rapamycin + Pazopanib Nab-rapamycin Pazopanib 0 1
Nab-rapamycin + Temozolomide Nab-rapamycin Temozolomide 0 1

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