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Therapy Name | A-485 + Alisertib |
Synonyms | |
Therapy Description | |
Drug Name | Trade Name | Synonyms | Drug Classes | Drug Description |
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A-485 | A385 | CBP/p300 inhibitor 13 | A-485 is a selective histone acetyltransferase inhibitor of EP300 and CREBBP, which induces cellular senescence, and may result in decreased cell proliferation and inhibition of tumor growth (PMID: 28953875, PMID: 30266801, PMID: 32366905). | |
Alisertib | MLN8237 | Aurka Inhibitors 27 | Alisertib (MLN8237) binds to and inhibits Aurora A kinase, which may result in disruption of the assembly of the mitotic spindle apparatus, disruption of chromosome segregation, and inhibition of cell proliferation (PMID: 26999067, PMID: 32414750). |
Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
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Clinical Trial | Phase | Therapies | Title | Recruitment Status | Covered Countries | Other Countries |
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