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|Therapy Name||Alisertib + MP7|
|Drug Name||Trade Name||Synonyms||Drug Classes||Drug Description|
|Alisertib||MLN8237||Aurka Inhibitors 24||Alisertib (MLN8237) binds to and inhibits Aurora A kinase, which may result in disruption of the assembly of the mitotic spindle apparatus, disruption of chromosome segregation, and inhibition of cell proliferation (PMID: 26999067, PMID: 32414750).|
|MP7||PDPK1 Inhibitor 10||MP7 is an inhibitor of phophoinostodine-dependent kinase (PDPK1), which, when combined with other agents, may result in inhibition of cell proliferation and reduced viability of cancer cells (PMID: 27797168).|
|Molecular Profile||Indication/Tumor Type||Response Type||Therapy Name||Approval Status||Evidence Type||Efficacy Evidence||References|
|Unknown unknown||glioblastoma multiforme||not applicable||Alisertib + MP7||Preclinical - Cell culture||Actionable||In a preclinical study, the combination of MP7 and Alisertib (MLN8237) resulted in an additive effect in glioblastoma cells in culture, demonstrating an increase in antiproliferative activity, decreased cell viability, and inhibition of glioma stem cell colony formation (PMID: 27797168).||27797168|
|Clinical Trial||Phase||Therapies||Title||Recruitment Status|