Drug Detail


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Drug Name MLN2480
Trade Name
Synonyms BIIB-024|TAK-580|MLN-2480|TAK580|DAY101|Tovorafenib
Drug Descriptions

MLN2480 (TAK-580) is an inhibitor of pan-Raf kinases, which interrupts RAF/MEK/ERK signal transduction pathways to inhibit tumor cell growth (PMID: 28082416, PMID: 30622172).

DrugClasses RAF Inhibitor (Pan) 23
CAS Registry Number 1096708-71-2
NCIT ID C106254


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Therapy Name Drugs Efficacy Evidence Clinical Trials
Alisertib + MLN2480 Alisertib MLN2480 0 1
MLN2480 MLN2480 6 5
MLN2480 + Nivolumab MLN2480 Nivolumab 0 2
MLN2480 + Paclitaxel MLN2480 Paclitaxel 0 1
MLN2480 + Sapanisertib MLN2480 Sapanisertib 0 1
MLN2480 + Selumetinib MLN2480 Selumetinib 0 0

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