Drug Detail

Contact

Missing content? – Request curation!

Request curation for specific Genes, variants, or PubMed publications.

Have questions, comments or suggestions? - Let us know!

Email us at : ckbsupport@jax.org

Drug Name MLN2480
Trade Name
Synonyms BIIB-024|TAK-580
Drug Descriptions

MLN2480 is an inhibitor of pan-Raf kinases, which interrupts RAF/MEK/ERK signal transduction pathways to inhibit tumor cell growth (NCI Drug Dictionary).

DrugClasses RAF Inhibitor (Pan) 16

Filtering

  • Case insensitive filtering will display rows where any text in any cell matches the filter term
  • Simple literal full or partial string matches
  • Separate multiple filter terms with a spaces, order doesn't matter (a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page, filtering has no impact on query parameters
  • Use quotes to match a longer phrase which contains spaces "mtor c1483f"

Sorting

  • Generally, the default sort order for tables is set to be first column ascending, however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column, be sure to set ascending or descending order for a given column, before moving on to the next column.

Therapy Name Drugs Efficacy Evidence Clinical Trials
Alisertib + MLN2480 Alisertib MLN2480 0 1
MLN2480 MLN2480 4 2
MLN2480 + Nivolumab MLN2480 Nivolumab 0 1
MLN2480 + Paclitaxel MLN2480 Paclitaxel 0 1
MLN2480 + Sapanisertib MLN2480 Sapanisertib 0 1
MLN2480 + Selumetinib MLN2480 Selumetinib 0 0


Additional content available in CKB BOOST