Drug Detail


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Drug Name Tovorafenib
Trade Name Ojemda
Synonyms BIIB-024|TAK-580|MLN-2480|TAK580|DAY101|MLN2480
Drug Descriptions

Ojemda (tovorafenib) is an inhibitor of pan-Raf kinases, which interrupts RAF/MEK/ERK signal transduction pathways to inhibit tumor cell growth (PMID: 28082416, PMID: 30622172). Ojemda (tovorafenib) is FDA approved for use in patients 6 months or older with relapsed or refractory pediatric low grade glioma harboring BRAF fusion or rearrangement or BRAF V600 mutation (FDA.gov).

DrugClasses RAF Inhibitor (Pan) 28
CAS Registry Number 1096708-71-2
NCIT ID C106254


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Therapy Name Drugs Efficacy Evidence Clinical Trials
Alisertib + Tovorafenib Alisertib Tovorafenib 0 1
Nivolumab + Tovorafenib Nivolumab Tovorafenib 0 2
Paclitaxel + Tovorafenib Paclitaxel Tovorafenib 0 1
Pimasertib + Tovorafenib Pimasertib Tovorafenib 0 1
Sapanisertib + Tovorafenib Sapanisertib Tovorafenib 0 1
Selumetinib + Tovorafenib Selumetinib Tovorafenib 0 0
Tovorafenib Tovorafenib 12 7
Tovorafenib + Vinblastine Tovorafenib Vinblastine 0 1

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