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Molecular Profile | EML4 - ALK ALK F1174C ALK E1210K |
Therapy | Lorlatinib |
Indication/Tumor Type | lung adenocarcinoma |
Response Type | predicted - sensitive |
Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
---|---|---|---|---|---|---|---|
EML4 - ALK ALK F1174C ALK E1210K | lung adenocarcinoma | predicted - sensitive | Lorlatinib | Case Reports/Case Series | Actionable | In a clinical case study, Lorbrena (lorlatinib) treatment resulted in a partial response in a patient with metastatic lung adenocarcinoma harboring EML4-ALK, ALK F1174C, and ALK E1210K (PMID: 34378333). | 34378333 |
PubMed Id | Reference Title | Details |
---|---|---|
(34378333) | Treatment of advanced lung cancer based on genomic profiling using liquid biopsy (plasma): A review of three cases. | Full reference... |