Therapy Detail
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| Therapy Name | NST-628 |
| Synonyms | |
| Therapy Description |
NST-628 stabilizes the RAF-MEK complex, which inhibits MEK/ERK/RSK phosphorylation and reactivation of the pathway, potentially leading to tumor growth inhibition (Mol Cancer Ther (2023) 22 (12_Supplement): A086, Mol Cancer Ther (2023) 22 (12_Supplement): A088). |
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| Drug Name | Trade Name | Synonyms | Drug Classes | Drug Description |
|---|---|---|---|---|
| NST-628 | NST628|NST 628 | NST-628 stabilizes the RAF-MEK complex, which inhibits MEK/ERK/RSK phosphorylation and reactivation of the pathway, potentially leading to tumor growth inhibition (Mol Cancer Ther (2023) 22 (12_Supplement): A086, Mol Cancer Ther (2023) 22 (12_Supplement): A088). |
Filtering
- Case insensitive filtering will display rows if any text in any cell matches the filter term
- Use simple literal full or partial string matches
- Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
- Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
- Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")
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| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|---|---|---|---|---|---|---|
| NRAS Q61L | melanoma | predicted - sensitive | NST-628 | Preclinical - Cell line xenograft | Actionable | In a preclinical study, NST-628 induced tumor regression in a melanoma cell line xenograft model harboring NRAS Q61L (Mol Cancer Ther (2023) 22 (12_Supplement): A088). | detail... |
| NRAS Q61R | melanoma | predicted - sensitive | NST-628 | Preclinical - Cell line xenograft | Actionable | In a preclinical study, NST-628 treatment resulted in tumor regression in an intracranial melanoma cell line xenograft model harboring NRAS Q61R (Mol Cancer Ther (2023) 22 (12_Supplement): A089). | detail... |
Filtering
- Case insensitive filtering will display rows if any text in any cell matches the filter term
- Use simple literal full or partial string matches
- Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
- Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
- Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")
Sorting
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- Click on any column header arrows to sort by that column
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| Clinical Trial | Phase | Therapies | Title | Recruitment Status | Covered Countries | Other Countries |
|---|---|---|---|---|---|---|
| NCT06326411 | Phase I | NST-628 | A Study to Investigate the Safety and Efficacy of NST-628 Oral Tablets in Subjects With Solid Tumors (NST-628) | Recruiting | AUS | 0 |
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