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Therapy Name NST-628
Synonyms
Therapy Description

NST-628 stabilizes the RAF-MEK complex, which inhibits MEK/ERK/RSK phosphorylation and reactivation of the pathway, potentially leading to tumor growth inhibition (Mol Cancer Ther (2023) 22 (12_Supplement): A086, Mol Cancer Ther (2023) 22 (12_Supplement): A088).

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Drug Name Trade Name Synonyms Drug Classes Drug Description
NST-628 NST628|NST 628 NST-628 stabilizes the RAF-MEK complex, which inhibits MEK/ERK/RSK phosphorylation and reactivation of the pathway, potentially leading to tumor growth inhibition (Mol Cancer Ther (2023) 22 (12_Supplement): A086, Mol Cancer Ther (2023) 22 (12_Supplement): A088).

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
NRAS Q61L melanoma predicted - sensitive NST-628 Preclinical - Cell line xenograft Actionable In a preclinical study, NST-628 induced tumor regression in a melanoma cell line xenograft model harboring NRAS Q61L (Mol Cancer Ther (2023) 22 (12_Supplement): A088). detail...
NRAS Q61R melanoma predicted - sensitive NST-628 Preclinical - Cell line xenograft Actionable In a preclinical study, NST-628 treatment resulted in tumor regression in an intracranial melanoma cell line xenograft model harboring NRAS Q61R (Mol Cancer Ther (2023) 22 (12_Supplement): A089). detail...

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
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Clinical Trial Phase Therapies Title Recruitment Status Covered Countries Other Countries
NCT06326411 Phase I NST-628 A Study to Investigate the Safety and Efficacy of NST-628 Oral Tablets in Subjects With Solid Tumors (NST-628) Recruiting USA | AUS 0


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