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Molecular Profile CDKN2A loss
Therapy Palbociclib
Indication/Tumor Type lung adenocarcinoma
Response Type predicted - sensitive

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
CDKN2A loss lung adenocarcinoma predicted - sensitive Palbociclib Clinical Study - Cohort Actionable In a Phase II trial (NLMT), Ibrance (palbociclib) treatment resulted in an observed objective response rate (ORR) of 4% (1/27), durable clinical benefit rate (DCBR) of 27.5% (8/29), and medial progression-free survival (PFS) of 3.3 months in patients with lung adenocarcinoma harboring CDKN2A loss, with Bayesian estimated OR and DCBR of 6% and 29%, respectively, and Bayesian posterior probability for PFS of 0.69 (PMID: 32669708, NCT02664935). 32669708
PubMed Id Reference Title Details
(32669708) The National Lung Matrix Trial of personalized therapy in lung cancer. Full reference...