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|Therapy Name||LXH 254|
LXH 254 is a RAF inhibitor that selectively inhibits monomeric and dimerized BRAF and CRAF, which may lead to anti-tumor activity in RAF-mutant tumors and better tolerability (AACR Annual Meeting 2019, Abstract LB-114).
|Drug Name||Trade Name||Synonyms||Drug Classes||Drug Description|
|LXH 254||LXH254|LXH-254||BRAF Inhibitor 20 CRAF Inhibitor 12||LXH 254 is a RAF inhibitor that selectively inhibits monomeric and dimerized BRAF and CRAF, which may lead to anti-tumor activity in RAF-mutant tumors and better tolerability (AACR Annual Meeting 2019, Abstract LB-114, PMID: 31059256).|
|Molecular Profile||Indication/Tumor Type||Response Type||Therapy Name||Approval Status||Evidence Type||Efficacy Evidence||References|
|BRAF mutant||Advanced Solid Tumor||predicted - sensitive||LXH 254||Case Reports/Case Series||Actionable||In a Phase I trial, LXH 254 treatment resulted in partial response in 2.6% (2/75) and stable disease in 33% (25/75) of patients with advanced solid tumors harboring MAPK pathway alterations, one of the patient achieved partial response harbored a BRAF mutation (J Clin Oncol 36, no. 15_suppl (May 20 2018) 2586-2586; NCT02607813).||detail...|
|Clinical Trial||Phase||Therapies||Title||Recruitment Status|
|NCT02607813||Phase I||LXH 254 + Spartalizumab LXH 254||Phase I Study of LXH254 in Patients With Advanced Solid Tumors Haboring MAPK Pathway Alterations||Recruiting|