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Molecular Profile Therapy Indication/Tumor Type Response Type Profile Response Detail
Unknown unknown Lestaurtinib pancreatic ductal adenocarcinoma not applicable detail...
Unknown unknown PI-3065 pancreatic ductal adenocarcinoma not applicable detail...
Unknown unknown Gemcitabine + MN58b pancreatic ductal adenocarcinoma not applicable detail...
Unknown unknown Fluorouracil + MN58b pancreatic ductal adenocarcinoma not applicable detail...
Unknown unknown MN58b + Oxaliplatin pancreatic ductal adenocarcinoma not applicable detail...
Unknown unknown Gemcitabine + Masitinib pancreatic ductal adenocarcinoma not applicable detail...
Unknown unknown MitoMet-10 pancreatic ductal adenocarcinoma not applicable detail...
Unknown unknown MitoMet-10 + Radiotherapy pancreatic ductal adenocarcinoma not applicable detail...
Unknown unknown JQ1 pancreatic ductal adenocarcinoma not applicable detail...
Unknown unknown Gemcitabine + JQ1 pancreatic ductal adenocarcinoma not applicable detail...
Unknown unknown Gemcitabine + Pelareorep pancreatic ductal adenocarcinoma not applicable detail...
Unknown unknown Selumetinib + SHP099 pancreatic ductal adenocarcinoma not applicable detail...
BRAF N486_P490del Trametinib pancreatic ductal adenocarcinoma predicted - sensitive detail...
Unknown unknown Arsenic trioxide + JQ1 pancreatic ductal adenocarcinoma not applicable detail...
Unknown unknown Arsenic trioxide + Chloroquine + JQ1 pancreatic ductal adenocarcinoma not applicable detail...
Unknown unknown Cisplatin + Gemcitabine pancreatic ductal adenocarcinoma not applicable detail...
PALB2 inact mut Cisplatin + Gemcitabine + Veliparib pancreatic ductal adenocarcinoma predicted - sensitive detail...
Unknown unknown LMB-100 + Nab-paclitaxel pancreatic ductal adenocarcinoma not applicable detail...
Unknown unknown Atezolizumab + BKT140 pancreatic ductal adenocarcinoma no benefit detail...
Unknown unknown Dinaciclib pancreatic ductal adenocarcinoma not applicable detail...
Unknown unknown Fluorouracil + Oxaliplatin + Veliparib pancreatic ductal adenocarcinoma not applicable detail...
PALB2 K346Tfs*13 Fluorouracil + Oxaliplatin + Veliparib pancreatic ductal adenocarcinoma predicted - sensitive detail...
ATM R3008C Fluorouracil + Oxaliplatin + Veliparib pancreatic ductal adenocarcinoma no benefit detail...
ATM T2333Nfs*40 Fluorouracil + Oxaliplatin + Veliparib pancreatic ductal adenocarcinoma no benefit detail...
Unknown unknown Gemcitabine + Nab-paclitaxel + PEGPH20 pancreatic ductal adenocarcinoma no benefit detail...
Unknown unknown Gemcitabine + Ipafricept + Nab-paclitaxel pancreatic ductal adenocarcinoma not applicable detail...
Unknown unknown Gemcitabine + Nab-paclitaxel + Vantictumab pancreatic ductal adenocarcinoma not applicable detail...
Unknown unknown Gemcitabine + Nab-paclitaxel + PF-04136309 pancreatic ductal adenocarcinoma no benefit detail...
Unknown unknown Gemcitabine + Nab-paclitaxel + Tarextumab pancreatic ductal adenocarcinoma no benefit detail...
Unknown unknown Gemcitabine + MM-141 + Nab-paclitaxel pancreatic ductal adenocarcinoma no benefit detail...
Unknown unknown Gemcitabine + Nab-paclitaxel + Necuparanib pancreatic ductal adenocarcinoma no benefit detail...
Unknown unknown Hydroxychloroquine + Trametinib pancreatic ductal adenocarcinoma not applicable detail...
Clinical Trial Phase Therapies Title Recruitment Status Covered Countries Other Countries
NCT01647828 Phase Ib/II Nab-paclitaxel Gemcitabine Tarextumab A Phase 1b/2 Study of OMP-59R5 in Combination With Nab-Paclitaxel and Gemcitabine in Subjects With Previously Untreated Stage IV Pancreatic Cancer Completed USA 0
NCT02042378 Phase II Rucaparib A Study of Rucaparib in Patients With Pancreatic Cancer and a Known Deleterious BRCA Mutation Completed USA 1
NCT02101021 Phase II Gemcitabine + Nab-paclitaxel Momelotinib Gemcitabine and Nab-paclitaxel Combined With Momelotinib in Participants With Previously Untreated Metastatic Pancreatic Ductal Adenocarcinoma Terminated USA 0
NCT02109445 Phase II Gemcitabine + Nab-paclitaxel PF-03084014 Study Of PF-03084014 In Combination With Gemcitabine And Nab-Paclitaxel In Patients With Metastatic Pancreatic Adenocarcinoma Not Previously Treated With Anticancer Therapies Terminated USA 0
NCT02241187 Phase I Cetuximab + PEGPH20 Two Stage Study Of Single Dose PEGPH20 And Cetuximab In Patients With Pancreatic Adenocarcinoma Prior To Surgical Resection Completed USA 0
NCT02259114 Phase I Birabresib A Phase IB Trial With OTX015, a Small Molecule Inhibitor of the Bromodomain and Extra-Terminal (BET) Proteins, in Patients With Selected Advanced Solid Tumors Completed 0
NCT02289898 Phase II Demcizumab + Gemcitabine + Nab-paclitaxel Study of Gemcitabine, Abraxane Plus Placebo Versus Gemcitabine, Abraxane Plus 1 or 2 Truncated Courses of Demcizumab in Subjects With 1st-Line Metastatic Pancreatic Ductal Adenocarcinoma Completed USA | CAN 4
NCT02362048 Phase II Acalabrutinib Pembrolizumab ACP-196 Alone and in Combination With Pembrolizumab in Subjects With Advanced or Metastatic Pancreatic Cancer Completed USA 0
NCT02501902 Phase I Nab-paclitaxel + Palbociclib Dose-Escalation Study Of Palbociclib + Nab-Paclitaxel In mPDAC Completed USA 1
NCT02559492 Phase I Epacadostat + Itacitinib Itacitinib + Parsaclisib INCB039110 Combined With INCB024360 and/or INCB039110 Combined With INCB050465 in Advanced Solid Tumors Terminated USA 0
NCT02583477 Phase Ib/II AZD5069 + Durvalumab Durvalumab + Gemcitabine + Nab-paclitaxel Phase Ib/II Study of MEDI4736 Evaluated in Different Combinations in Metastatic Pancreatic Ductal Carcinoma Completed USA 1
NCT02600949 Phase I Pembrolizumab Peptide Vaccine in Advanced Pancreatic Ductal Adenocarcinoma or Colorectal Adenocarcinoma Recruiting USA 0
NCT02672917 Phase I MVT-5873 Study of HuMab-5B1 (MVT-5873) in Subjects With Pancreatic Cancer or Other Cancer Antigen 19-9 (CA19-9) Positive Malignancies Recruiting USA 0
NCT02705196 Phase Ib/II Atezolizumab + Gemcitabine + LOAd703 + Nab-paclitaxel Gemcitabine + LOAd703 + Nab-paclitaxel LOAd703 Oncolytic Virus Therapy for Pancreatic Cancer Recruiting USA 0
NCT02732938 Phase I Gemcitabine + Nab-paclitaxel + PF-04136309 Ph1b/2 Study of PF-04136309 in Combination With Gem/Nab-P in First-line Metastatic Pancreatic Patients (CCR2i) Terminated USA 0
NCT02754726 Phase II Cisplatin + Gemcitabine + Nab-paclitaxel + Nivolumab + Paricalcitol Combination Therapy for Patients With Untreated Metastatic Pancreatic Ductal Adenocarcinoma Recruiting USA 0
NCT02810418 Phase Ib/II LMB-100 LMB-100 + Nab-paclitaxel Mesothelin-Targeted Immunotoxin LMB-100 Alone or in Combination With Nab-Paclitaxel in People With Previously Treated Metastatic and/or Locally Advanced Pancreatic Ductal Adenocarcinoma and Mesothelin Expressing Solid Tumors Active, not recruiting USA 0
NCT02857270 Phase I LY3214996 Gemcitabine + LY3214996 + Nab-paclitaxel LY3214996 + Midazolam Abemaciclib + LY3214996 A Study of LY3214996 Administered Alone or in Combination With Other Agents in Participants With Advanced/Metastatic Cancer Active, not recruiting USA 3
NCT02879318 Phase II Gemcitabine + Nab-paclitaxel Durvalumab + Tremelimumab Gemcitabine and Nab-Paclitaxel vs Gemcitabine, Nab-Paclitaxel, Durvalumab and Tremelimumab as 1st Line Therapy in Pancreatic Adenocarcinoma Active, not recruiting CAN 0
NCT02880371 Phase Ib/II ARRY-382 + Pembrolizumab A Study of ARRY-382 in Combination With Pembrolizumab for the Treatment of Patients With Advanced Solid Tumors Completed USA 0
NCT02921022 Phase 0 Gemcitabine + Nab-paclitaxel + PEGPH20 Study Of Gemcitabine, Nab-paclitaxel, PEGPH20 and Rivaroxaban for Advanced Pancreatic Adenocarcinoma Active, not recruiting USA 0
NCT02942095 Phase I Erlotinib + Ixazomib Study of Ixazomib and Erlotinib in Solid Tumors Active, not recruiting USA 0
NCT02978547 Phase II Metformin The Effects of Neoadjuvant Metformin on Tumour Cell Proliferation and Tumour Progression in Pancreatic Ductal Adenocarcinoma (Metformin 001) Unknown status CAN 0
NCT02981342 Phase II Capecitabine Abemaciclib Gemcitabine Abemaciclib + LY3023414 Abemaciclib + Galunisertib A Study of Abemaciclib (LY2835219) Alone or in Combination With Other Agents in Participants With Previously Treated Pancreatic Ductal Adenocarcinoma Completed USA 7
NCT02993731 Phase III Gemcitabine + Nab-paclitaxel + Napabucasin Gemcitabine + Nab-paclitaxel A Study of Napabucasin Plus Nab-Paclitaxel With Gemcitabine in Adult Patients With Metastatic Pancreatic Adenocarcinoma (CanStem111P) Completed USA | CAN 18
NCT03038477 Phase II Durvalumab A Study of Durvalumab in Patients With Borderline Resectable Pancreas Adenocarcinoma Following Neoadjuvant Therapy and Successful Surgical Resection Withdrawn USA 0
NCT03076372 Phase I MM-310 A Study Evaluating MM-310 in Patients With Solid Tumors Unknown status USA 0
NCT03118349 Phase I MVT-1075 + MVT-5873 Study of 177Lu Human Monoclonal Antibody 5B1 (MVT-1075) in Combination With a Blocking Dose of MVT-5873 as Radioimmunotherapy Suspended USA 0
NCT03193190 Phase Ib/II Atezolizumab + BKT140 Fluorouracil + Gemcitabine + Leucovorin + Nab-paclitaxel + Oxaliplatin + Pembrolizumab Atezolizumab + PEGPH20 Atezolizumab + Cobimetinib A Study of Multiple Immunotherapy-Based Treatment Combinations in Participants With Metastatic Pancreatic Ductal Adenocarcinoma (PDAC) Recruiting USA 4
NCT03264404 Phase II Azacitidine + Pembrolizumab Azacitidine and Pembrolizumab in Pancreatic Cancer Recruiting USA 0
NCT03412799 Phase I Gemcitabine + Nab-paclitaxel + SBP-101 Study of SBP-101 Combined With Nab-Paclitaxel and Gemcitabine in Pancreatic Cancer Recruiting USA 1
NCT03415126 Phase I ASN007 A Study of ASN007 in Patients With Advanced Solid Tumors Completed USA 0
NCT03415854 Phase II Cisplatin + Gemcitabine + Nab-paclitaxel + Paricalcitol Paclitaxel Protein Bound Plus Cisplatin Plus Gemcitabine and Paricalcitol for Pancreatic Adenocarcinoma (NABPLAGEMD) (NABPLAGEMD) Active, not recruiting USA 0
NCT03425279 Phase Ib/II CAB-AXL-ADC CAB-AXL-ADC Safety and Efficacy Study in Patients With Solid Tumors Recruiting USA 0
NCT03432676 Phase II Epacadostat + Pembrolizumab Study of IDO-1 Inhibitor Epacadostat in Combination With Pembrolizumab in Advanced Pancreatic Cancer With Chromosomal Instability/ Homologous Recombination Repair Deficiency (HRD) Withdrawn 0
NCT03435250 Phase I AG-270 + Docetaxel AG-270 + Gemcitabine + Nab-paclitaxel AG-270 Study of AG-270 in Participants With Advanced Solid Tumors or Lymphoma With MTAP Loss Recruiting USA 2
NCT03450018 Phase Ib/II Gemcitabine + SLC-0111 A Study of SLC-0111 and Gemcitabine for Metastatic Pancreatic Ductal Cancer in Subjects Positive for CAIX (SLC-0111-17-01) Recruiting CAN 0
NCT03496662 Phase Ib/II Nivolumab BMS-813160 + Gemcitabine + Nab-paclitaxel Gemcitabine + Nab-paclitaxel BMS-813160 + Gemcitabine + Nab-paclitaxel + Nivolumab BMS-813160 With Nivolumab and Gemcitabine and Nab-paclitaxel in Borderline Resectable and Locally Advanced Pancreatic Ductal Adenocarcinoma (PDAC) Recruiting USA 0
NCT03592888 Phase I mDC3/8-KRAS vaccine DC Vaccine in Pancreatic Cancer Recruiting USA 0
NCT03608631 Phase I iExosomes iExosomes in Treating Participants With Metastatic Pancreas Cancer With KrasG12D Mutation Recruiting USA 0
NCT03610490 Phase II Aldesleukin + Cyclophosphamide + Fludarabine + MDA autologous tumor-infiltrating lymphocytes Autologous Tumor Infiltrating Lymphocytes MDA-TIL in Treating Patients With Recurrent or Refractory Ovarian Cancer, Colorectal Cancer, or Pancreatic Ductal Adenocarcinoma Recruiting USA 0
NCT03634332 Phase II PEGPH20 + Pembrolizumab Second-line Study of PEGPH20 and Pembro for HA High Metastatic PDAC Unknown status USA 0
NCT03637491 Phase II Avelumab + Binimetinib + Talazoparib Avelumab + Binimetinib A Study of Avelumab, Binimetinib and Talazoparib in Patients With Locally Advanced or Metastatic RAS-mutant Solid Tumors Terminated USA 2
NCT03681951 Phase Ib/II GSK3145095 GSK3145095 + Pembrolizumab First-time-in-human (FTIH) Study of GSK3145095 Alone and in Combination With Other Anticancer Agents in Adults With Advanced Solid Tumors Terminated USA 0
NCT03682289 Phase II AZD6738 + Olaparib Olaparib Phase II Trial of AZD6738 Alone and in Combination With Olaparib Recruiting USA 0
NCT03727880 Phase II Defactinib + Pembrolizumab Pembrolizumab Study of Pembrolizumab With or Without Defactinib Following Chemotherapy as a Neoadjuvant and Adjuvant Treatment for Resectable Pancreatic Ductal Adenocarcinoma Recruiting USA 0
NCT03733990 Phase Ib/II FP-1305 A Study to Evaluate Safety, Tolerability and Preliminary Efficacy of FP-1305 in Cancer Patients (MATINS) Recruiting USA 5
NCT03811652 Phase I MEDI7247 A Multiple Ascending Dose Study of MEDI7247 in Advanced or Metastatic Solid Tumors Completed USA | CAN 0
NCT03953235 Phase Ib/II GRT-C903 + GRT-R904 + Ipilimumab + Nivolumab A Study of a Personalized Cancer Vaccine Targeting Shared Neoantigens Recruiting USA 0
NCT03979066 Phase II Atezolizumab Atezolizumab + PEGPH20 Study Evaluating NEOadjuvant Immunotherapy in Resectable PANCreatic Ductal Adenocarcinoma (NEOiPANC) Terminated USA 0
NCT04042480 Phase I SGN-CD228A A Study of SGN-CD228A in Advanced Solid Tumors Recruiting USA 4
NCT04111172 Phase II Ad5.F35-hGCC-PADRE Phase 2A Study of Ad5.F35-hGCC-PADRE in Gastrointestinal Malignancies Recruiting USA 0
NCT04161755 Phase I Atezolizumab + Fluorouracil + Irinotecan + Leucovorin + Oxaliplatin + RO7198457 Study of Personalized Tumor Vaccines (PCVs) and a PD-L1 Blocker in Patients With Pancreatic Cancer That Can be Treated With Surgery Recruiting USA 0
NCT04262388 Phase II Durvalumab + Oleclumab A Multi-Cancer, Multi-State, Platform Study of Durvalumab (MEDI4736) and Oleclumab (MEDI9447) in Pancreatic Adenocarcinoma, Non-Small Cell Lung Cancer and Squamous Cell Carcinoma of the Head and Neck to Correlate Clinical, Molecular and Immunologic Parameters With DNA Methylation (DOME) Withdrawn CAN 0
NCT04477343 Phase I Nivolumab + SX-682 A Study to Evaluate the Safety and Tolerability of SX-682 in Combination With Nivolumab as a Maintenance Therapy in Patients With Metastatic Pancreatic Ductal Adenocarcinoma Recruiting USA 0
NCT04493060 Phase II Dostarlimab-gxly + Niraparib Niraparib and Dostarlimab for Treatment of Germline or Somatic BRCA1/2 and PALB2 Mutated Metastatic Pancreatic Cancer Recruiting USA 0
NCT04536077 Phase II CDX-1140 + CDX-301 CDX-1140 Immunologic Effects of CDX-301 and CDX-1140 in Resectable Pancreatic Cancer Patients Recruiting USA 0
NCT04581343 Phase I Canakinumab + Gemcitabine + Nab-paclitaxel + Spartalizumab A Phase 1B Study of Canakinumab, Spartalizumab, Nab-paclitaxel, and Gemcitabine in Metastatic PC Patients (PanCAN-SR1) Recruiting USA 0
NCT04672434 Phase I Sym021 + Sym024 Sym024 Sym024 Monotherapy and in Combination With Sym021 in Patients With Advanced Solid Tumor Malignancies Recruiting USA | CAN 0
NCT04704154 Phase II Nivolumab + Regorafenib A Trial to Learn Whether Regorafenib in Combination With Nivolumab Can Improve Tumor Responses and How Safe it is for Participants With Solid Tumors Recruiting USA 7
NCT04752696 Phase II Fluorouracil + Leucovorin + MM-398 + Onvansertib Onvansertib in Combination With Nanoliposomal Irinotecan, Leucovorin, and Fluorouracil for Second-Line Treatment of Participants With Metastatic Pancreatic Ductal Adenocarcinoma Recruiting USA 0
NCT04753879 Phase II Olaparib + Pembrolizumab Capecitabine + Cisplatin + Gemcitabine + Irinotecan + Nab-paclitaxel Multi-agent Low Dose Chemotherapy GAX-CI Followed by Olaparib and Pembro in Metastatic Pancreatic Ductal Cancer. Not yet recruiting USA 0
NCT04853017 Phase Ib/II ELI-002 A Study of ELI-002 in Subjects With KRAS Mutated Pancreatic Ductal Adenocarcinoma (PDAC) and Other Solid Tumor (AMPLIFY-201) Recruiting USA 0