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Therapy Name C188-9
Synonyms
Therapy Description

C188-9 (TTI-101) is a small molecule that binds to STAT3 and inhibits signaling, potentially resulting in tumor cell death (PMID: 27027445, PMID: 32475130).

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Drug Name Trade Name Synonyms Drug Classes Drug Description
C188-9 TTI101|TTI-101|TTI 101 STAT3 Inhibitor 26 C188-9 (TTI-101) is a small molecule that binds to STAT3 and inhibits signaling, potentially resulting in tumor cell death (PMID: 27027445, PMID: 32475130).

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column. Be sure to set ascending or descending order for a given column before moving on to the next column.

Clinical Trial Phase Therapies Title Recruitment Status Covered Countries Other Countries
NCT03195699 Phase I C188-9 Phase I Study of Oral STAT3 Inhibitor, C188-9, in Patients With Advanced Cancers Active, not recruiting USA 0
NCT06141031 Phase Ib/II C188-9 Phase 1/2 Trial of Radiotherapy in Combination With TTI-101 in Patients With Borderline Resectable Pancreatic Cancer Recruiting USA 0
NCT05440708 Phase Ib/II Atezolizumab + Bevacizumab + C188-9 C188-9 C188-9 + Pembrolizumab A Study of TTI-101 as Monotherapy and in Combination in Participants With Locally Advanced or Metastatic, and Unresectable Hepatocellular Carcinoma Recruiting USA 0
NCT05845307 Phase I C188-9 Randomized Pre-surgical Window-of-Opportunity Trial of TTI-101 in Patients With Stage II-IV Resectable HPV-negative Squamous Cell Carcinoma of the Head and Neck Not yet recruiting USA 0


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