Therapy Detail
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| Therapy Name | C188-9 |
| Synonyms | |
| Therapy Description |
C188-9 (TTI-101) is a small molecule that binds to STAT3 and inhibits signaling, potentially resulting in tumor cell death (PMID: 27027445, PMID: 32475130). |
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| Drug Name | Trade Name | Synonyms | Drug Classes | Drug Description |
|---|---|---|---|---|
| C188-9 | TTI101|TTI-101|TTI 101 | STAT3 Inhibitor 26 | C188-9 (TTI-101) is a small molecule that binds to STAT3 and inhibits signaling, potentially resulting in tumor cell death (PMID: 27027445, PMID: 32475130). |
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- Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")
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| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|
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| Clinical Trial | Phase | Therapies | Title | Recruitment Status | Covered Countries | Other Countries |
|---|---|---|---|---|---|---|
| NCT03195699 | Phase I | C188-9 | Phase I Study of Oral STAT3 Inhibitor, C188-9, in Patients With Advanced Cancers | Active, not recruiting | USA | 0 |
| NCT06141031 | Phase Ib/II | C188-9 | Phase 1/2 Trial of Radiotherapy in Combination With TTI-101 in Patients With Borderline Resectable Pancreatic Cancer | Recruiting | USA | 0 |
| NCT05845307 | Phase I | C188-9 | Randomized Pre-surgical Window-of-Opportunity Trial of TTI-101 in Patients With Stage II-IV Resectable HPV-negative Squamous Cell Carcinoma of the Head and Neck | Not yet recruiting | USA | 0 |
| NCT05440708 | Phase Ib/II | Atezolizumab + Bevacizumab + C188-9 C188-9 C188-9 + Pembrolizumab | A Study of TTI-101 as Monotherapy and in Combination in Participants With Locally Advanced or Metastatic, and Unresectable Hepatocellular Carcinoma | Recruiting | USA | 0 |
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