Therapy Detail

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Therapy Name AB680 + Etrumadenant + Zimberelimab
Synonyms
Therapy Description

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Drug Name Trade Name Synonyms Drug Classes Drug Description
AB680 AB-680|AB 680|quemliclustat Adenosine Targeting 23 CD73 Antibody 12 AB680 is an inhibitor that selectively targets CD73, resulting in decreased production of extracellular adenosine (ADO), and potentially leading to decreased ADO-mediated T-cell suppression and improved anti-tumor immunity (Cancer Res 2018;78(13 Suppl):Abstract nr 1756, PMID: 32614585).
Etrumadenant AB 928|AB-928|AB928 Adenosine Targeting 23 Etrumadenant is an antagonist of the adenosine receptors, A2aR and A2bR, which may relieve adenosine-mediated immune suppression and lead to enhanced anti-tumor activity in combination with other agents (European Journal of Cancer, Vol 92, S14-S15, PMID: 30569245).
Zimberelimab GLS-010|AB122|AB-122|GLS010 Immune Checkpoint Inhibitor 146 PD-L1/PD-1 antibody 114 Zimberelimab (GLS-010) is a monoclonal antibody that targets PD-1 (PDCD1) and inhibits binding of the PD-L1 (CD274) ligand, potentially resulting in enhanced anti-tumor immune response (PMID: 28679395).

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
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Clinical Trial Phase Therapies Title Recruitment Status Covered Countries Other Countries
NCT04381832 Phase Ib/II Enzalutamide + Etrumadenant + Zimberelimab Docetaxel + Etrumadenant + Zimberelimab AB680 + Etrumadenant + Zimberelimab AB680 + Etrumadenant Enzalutamide Docetaxel Etrumadenant + Zimberelimab Adenosine Receptor Antagonist Combination Therapy for Metastatic Castrate Resistant Prostate Cancer (ARC-6) Active, not recruiting USA | CAN 0
NCT06048484 Phase II Fluorouracil + Irinotecan + Leucovorin + Oxaliplatin + Pegfilgrastim AB680 + Etrumadenant + Zimberelimab AB680 + Zimberelimab Zimberelimab Combination Therapy in Patients With Localized Pancreatic Ductal Adenocarcinoma (AIRPanc) Recruiting USA 0
NCT04660812 Phase Ib/II AB680 + Etrumadenant + Zimberelimab Regorafenib Bevacizumab + Etrumadenant + Fluorouracil + Leucovorin + Oxaliplatin + Zimberelimab Etrumadenant + Fluorouracil + Leucovorin + Oxaliplatin + Zimberelimab Bevacizumab + Fluorouracil + Leucovorin + Oxaliplatin An Open Label Study Evaluating the Efficacy and Safety of AB928 Based Treatment Combinations in Patients With Metastatic Colorectal Cancer. Active, not recruiting USA | ITA | GBR | FRA | ESP 1
NCT05915442 Phase II AB680 + Etrumadenant + Zimberelimab Adenosine Signaling Modulation and Immune Checkpoint Inhibition With Hormone Sensitive Oligometastatic Prostate Cancer (SBRT-AMICO) Recruiting USA 0


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