Drug Detail


Missing content? – Request curation!

Request curation for specific Genes, Variants, or PubMed publications.

Have questions, comments, or suggestions? - Let us know!

Email us at : ckbsupport@jax.org

Drug Name AB680
Trade Name
Synonyms AB-680|AB 680|quemliclustat
Drug Descriptions

AB680 is an inhibitor that selectively targets CD73, resulting in decreased production of extracellular adenosine (ADO), and potentially leading to decreased ADO-mediated T-cell suppression and improved anti-tumor immunity (Cancer Res 2018;78(13 Suppl):Abstract nr 1756, PMID: 32614585).

DrugClasses Adenosine Targeting 23 CD73 Antibody 11
CAS Registry Number 2105904-82-1
NCIT ID C167156


  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")


  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column. Be sure to set ascending or descending order for a given column before moving on to the next column.

Therapy Name Drugs Efficacy Evidence Clinical Trials
AB154 + AB680 + Zimberelimab AB154 AB680 Zimberelimab 0 1
AB680 AB680 0 0
AB680 + Cisplatin + Gemcitabine + Zimberelimab AB680 Cisplatin Gemcitabine Zimberelimab 0 1
AB680 + Docetaxel + Zimberelimab AB680 Docetaxel Zimberelimab 0 1
AB680 + Etrumadenant AB680 Etrumadenant 0 1
AB680 + Etrumadenant + Zimberelimab AB680 Etrumadenant Zimberelimab 0 4
AB680 + Gemcitabine + Nab-paclitaxel + Zimberelimab AB680 Gemcitabine Nab-paclitaxel Zimberelimab 0 0
AB680 + Irinotecan + Leucovorin + Oxaliplatin + Zimberelimab AB680 Irinotecan Leucovorin Oxaliplatin Zimberelimab 0 1
AB680 + unspecified PD-1 antibody AB680 unspecified PD-1 antibody 0 0
AB680 + Zimberelimab AB680 Zimberelimab 0 4

Additional content available in CKB BOOST