Drug Detail


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Drug Name AB680
Trade Name
Synonyms AB-680|AB 680|quemliclustat
Drug Descriptions

AB680 is an inhibitor that selectively targets CD73, resulting in decreased production of extracellular adenosine (ADO), and potentially leading to decreased ADO-mediated T-cell suppression and improved anti-tumor immunity (Cancer Res 2018;78(13 Suppl):Abstract nr 1756, PMID: 32614585).

DrugClasses Adenosine Targeting 19 CD73 Antibody 10
CAS Registry Number 2105904-82-1
NCIT ID C167156


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Therapy Name Drugs Efficacy Evidence Clinical Trials
AB680 AB680 0 0
AB680 + AB928 AB680 AB928 0 1
AB680 + AB928 + Zimberelimab AB680 AB928 Zimberelimab 0 2
AB680 + Gemcitabine + Nab-paclitaxel + Zimberelimab AB680 Gemcitabine Nab-paclitaxel Zimberelimab 0 0
AB680 + unspecified PD-1 antibody AB680 unspecified PD-1 antibody 0 0
AB680 + Zimberelimab AB680 Zimberelimab 0 1

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