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Drug Name Zimberelimab
Trade Name
Synonyms GLS-010|AB122|AB-122|GLS010
Drug Descriptions

Zimberelimab (GLS-010) is a monoclonal antibody that targets PD-1 (PDCD1) and inhibits binding of the PD-L1 (CD274) ligand, potentially resulting in enhanced anti-tumor immune response (PMID: 28679395).

DrugClasses Immune Checkpoint Inhibitor 148 PD-L1/PD-1 antibody 93
CAS Registry Number NA
NCIT ID C159549

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Therapy Name Drugs Efficacy Evidence Clinical Trials
AB154 + AB928 + Zimberelimab AB154 AB928 Zimberelimab 0 2
AB154 + APX005M + Zimberelimab AB154 APX005M Zimberelimab 0 1
AB154 + Fluorouracil + Leucovorin + Oxaliplatin + Zimberelimab AB154 Fluorouracil Leucovorin Oxaliplatin Zimberelimab 0 1
AB154 + Zimberelimab AB154 Zimberelimab 0 5
AB308 + Zimberelimab AB308 Zimberelimab 0 1
AB680 + AB928 + Zimberelimab AB680 AB928 Zimberelimab 0 2
AB680 + Gemcitabine + Nab-paclitaxel + Zimberelimab AB680 Gemcitabine Nab-paclitaxel Zimberelimab 0 0
AB680 + Zimberelimab AB680 Zimberelimab 0 1
AB928 + Bevacizumab + Fluorouracil + Leucovorin + Oxaliplatin + Zimberelimab AB928 Bevacizumab Fluorouracil Leucovorin Oxaliplatin Zimberelimab 0 1
AB928 + Cisplatin + Zimberelimab AB928 Cisplatin Zimberelimab 0 1
AB928 + Docetaxel + Zimberelimab AB928 Docetaxel Zimberelimab 0 1
AB928 + Enzalutamide + Zimberelimab AB928 Enzalutamide Zimberelimab 0 1
AB928 + Fluorouracil + Leucovorin + Oxaliplatin + Zimberelimab AB928 Fluorouracil Leucovorin Oxaliplatin Zimberelimab 0 2
AB928 + Pemetrexed Disodium + Zimberelimab AB928 Pemetrexed Disodium Zimberelimab 0 1
AB928 + SRF617 + Zimberelimab AB928 SRF617 Zimberelimab 0 1
AB928 + Zimberelimab AB928 Zimberelimab 0 2
Cisplatin + Zimberelimab Cisplatin Zimberelimab 0 1
Zimberelimab Zimberelimab 0 4


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