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Drug Name Etrumadenant
Trade Name
Synonyms AB 928|AB-928|AB928
Drug Descriptions

Etrumadenant is an antagonist of the adenosine receptors, A2aR and A2bR, which may relieve adenosine-mediated immune suppression and lead to enhanced anti-tumor activity in combination with other agents (European Journal of Cancer, Vol 92, S14-S15, PMID: 30569245).

DrugClasses Adenosine Targeting 23
CAS Registry Number 2239273-34-6
NCIT ID C159564

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Therapy Name Drugs Efficacy Evidence Clinical Trials
AB154 + Etrumadenant + Zimberelimab AB154 Etrumadenant Zimberelimab 0 3
AB680 + Etrumadenant AB680 Etrumadenant 0 1
AB680 + Etrumadenant + Zimberelimab AB680 Etrumadenant Zimberelimab 0 4
Bevacizumab + Etrumadenant + Fluorouracil + Leucovorin + Oxaliplatin + Zimberelimab Bevacizumab Etrumadenant Fluorouracil Leucovorin Oxaliplatin Zimberelimab 0 1
Carboplatin + Etrumadenant + Pembrolizumab + Pemetrexed Disodium Carboplatin Etrumadenant Pembrolizumab Pemetrexed Disodium 0 1
Carboplatin + Etrumadenant + Pemetrexed Disodium Carboplatin Etrumadenant Pemetrexed Disodium 0 1
Cisplatin + Etrumadenant + Zimberelimab Cisplatin Etrumadenant Zimberelimab 0 1
Docetaxel + Etrumadenant + Zimberelimab Docetaxel Etrumadenant Zimberelimab 0 1
Doxorubicin + Etrumadenant Doxorubicin Etrumadenant 0 0
Eganelisib + Etrumadenant + Pegylated liposomal doxorubicin Eganelisib Etrumadenant Pegylated liposomal doxorubicin 0 1
Enzalutamide + Etrumadenant + Zimberelimab Enzalutamide Etrumadenant Zimberelimab 0 1
Etrumadenant Etrumadenant 0 0
Etrumadenant + Fluorouracil + Leucovorin + Oxaliplatin Etrumadenant Fluorouracil Leucovorin Oxaliplatin 0 1
Etrumadenant + Fluorouracil + Leucovorin + Oxaliplatin + Zimberelimab Etrumadenant Fluorouracil Leucovorin Oxaliplatin Zimberelimab 0 2
Etrumadenant + Oxaliplatin Etrumadenant Oxaliplatin 0 0
Etrumadenant + Pegylated liposomal doxorubicin Etrumadenant Pegylated liposomal doxorubicin 0 1
Etrumadenant + Pemetrexed Disodium + Zimberelimab Etrumadenant Pemetrexed Disodium Zimberelimab 0 1
Etrumadenant + Sacituzumab govitecan-hziy + Zimberelimab Etrumadenant Sacituzumab govitecan-hziy Zimberelimab 0 1
Etrumadenant + SRF617 + Zimberelimab Etrumadenant SRF617 Zimberelimab 0 1
Etrumadenant + Zimberelimab Etrumadenant Zimberelimab 0 4


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