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Therapy Name | Ifinatamab deruxtecan |
Synonyms | |
Therapy Description |
Ifinatamab deruxtecan (DS-7300a) is a monoclonal antibody targeting B7-H3 (CD276) conjugated to a DNA topoisomerase I inhibitor which may lead to antitumor activities (Ann Oncol (2023) 34 (suppl_2):S481-S482). |
Drug Name | Trade Name | Synonyms | Drug Classes | Drug Description |
---|---|---|---|---|
Ifinatamab deruxtecan | DS7300a|DS 7300a|DS7300|DS 7300|DS-7300|DS-7300a|I-DXd | CD276 Antibody 12 | Ifinatamab deruxtecan (DS-7300a) is a monoclonal antibody targeting B7-H3 (CD276) conjugated to a DNA topoisomerase I inhibitor which may lead to antitumor activities (Ann Oncol (2023) 34 (suppl_2):S481-S482). |
Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
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Clinical Trial | Phase | Therapies | Title | Recruitment Status | Covered Countries | Other Countries |
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NCT05280470 | Phase II | Ifinatamab deruxtecan | DS-7300a in Subjects With Pretreated Extensive-Stage Small Cell Lung Cancer (ES-SCLC) | Recruiting | USA | FRA | ESP | DEU | AUT | 4 |
NCT04145622 | Phase Ib/II | Ifinatamab deruxtecan | Study of DS-7300a in Participants With Advanced Solid Malignant Tumors | Recruiting | USA | 1 |