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Therapy Name Ifinatamab deruxtecan
Synonyms
Therapy Description

Ifinatamab deruxtecan (DS-7300a) is a monoclonal antibody targeting B7-H3 (CD276) conjugated to a DNA topoisomerase I inhibitor which may lead to antitumor activities (Ann Oncol (2023) 34 (suppl_2):S481-S482).

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Drug Name Trade Name Synonyms Drug Classes Drug Description
Ifinatamab deruxtecan DS7300a|DS 7300a|DS7300|DS 7300|DS-7300|DS-7300a|I-DXd CD276 Antibody 13 Ifinatamab deruxtecan (DS-7300a) is a monoclonal antibody targeting B7-H3 (CD276) conjugated to a DNA topoisomerase I inhibitor which may lead to antitumor activities (Ann Oncol (2023) 34 (suppl_2):S481-S482).

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column. Be sure to set ascending or descending order for a given column before moving on to the next column.

Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column. Be sure to set ascending or descending order for a given column before moving on to the next column.

Clinical Trial Phase Therapies Title Recruitment Status Covered Countries Other Countries
NCT06330064 Phase II Ifinatamab deruxtecan A Study To Evaluate The Efficacy And Safety Of Ifinatamab Deruxtecan (I-DXD) In Subjects With Recurrent Or Metastatic Solid Tumors Recruiting USA 0
NCT04145622 Phase Ib/II Ifinatamab deruxtecan Study of DS-7300a in Participants With Advanced Solid Malignant Tumors Recruiting USA 1
NCT05280470 Phase II Ifinatamab deruxtecan DS-7300a in Subjects With Pretreated Extensive-Stage Small Cell Lung Cancer (ES-SCLC) Recruiting USA | FRA | ESP | DEU | AUT 4
NCT06203210 Phase III Ifinatamab deruxtecan Amrubicin Lurbinectedin Topotecan A Study of Ifinatamab Deruxtecan Versus Treatment of Physician's Choice in Subjects With Relapsed Small Cell Lung Cancer (IDeate-Lung02) Not yet recruiting USA | NLD | ITA | GBR | FRA | ESP | DEU | CAN | BEL | AUS 11


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