Disease Detail

ID DOID:4074
Name pancreatic adenocarcinoma
Definition A pancreatic carcinoma that derives_from epithelial cells of glandular origin.
Source DiseaseOntology.org
Alt Ids
Path disease disease of cellular proliferation cancer organ system cancer endocrine gland cancer pancreatic cancer pancreatic carcinoma pancreatic adenocarcinoma

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Molecular Profile Therapy Indication/Tumor Type Response Type Profile Response Detail
Unknown unknown Cabozantinib pancreatic adenocarcinoma not applicable detail...
Unknown unknown Gemcitabine + Pimasertib pancreatic adenocarcinoma not applicable detail...
Unknown unknown Gemcitabine + Vandetanib pancreatic adenocarcinoma not applicable detail...
KRAS mutant BI-847325 pancreatic adenocarcinoma sensitive detail...
PTEN loss KRAS G12D MK2206 pancreatic adenocarcinoma sensitive detail...
Unknown unknown Gemcitabine + Pri-724 pancreatic adenocarcinoma not applicable detail...
Unknown unknown Capecitabine + Ruxolitinib pancreatic adenocarcinoma not applicable detail...
Unknown unknown CGP57380 pancreatic adenocarcinoma not applicable detail...
BRAF mutant Trametinib pancreatic adenocarcinoma sensitive detail...
KRAS mutant Trametinib pancreatic adenocarcinoma sensitive detail...
Unknown unknown Bevacizumab + Erlotinib + Gemcitabine pancreatic adenocarcinoma no benefit detail...
Unknown unknown GSK1904529A pancreatic adenocarcinoma not applicable detail...
KRAS G12C BI-847325 pancreatic adenocarcinoma sensitive detail...
KRAS mutant PF-00477736 + PF3644022 pancreatic adenocarcinoma predicted - sensitive detail...
Unknown unknown MK2206 + Selumetinib pancreatic adenocarcinoma no benefit detail...
KRAS G12C Selumetinib pancreatic adenocarcinoma sensitive detail...
KRAS G12C PD-0325901 pancreatic adenocarcinoma sensitive detail...
KRAS G12C Refametinib pancreatic adenocarcinoma sensitive detail...
KRAS G12C Trametinib pancreatic adenocarcinoma sensitive detail...
Unknown unknown Gemcitabine + NSC109555 pancreatic adenocarcinoma not applicable detail...
KRAS G12D RAF709 + Trametinib pancreatic adenocarcinoma sensitive detail...
Clinical Trial Phase Therapies Title Recruitment Status
NCT00602602 Phase II Bevacizumab + Fluorouracil + Oxaliplatin Bevacizumab + Gemcitabine + Oxaliplatin Bevacizumab + Gemcitabine Bevacizumab, Combination Chemotherapy, and Radiation Therapy in Treating Patients Undergoing Surgery For Locally Advanced Pancreatic Cancer Active, not recruiting
NCT01013649 Phase II Erlotinib + Gemcitabine Gemcitabine Gemcitabine Hydrochloride With or Without Erlotinib Hydrochloride Followed By the Same Chemotherapy Regimen With or Without Radiation Therapy and Capecitabine or Fluorouracil in Treating Patients With Pancreatic Cancer That Has Been Removed By Surgery Active, not recruiting
NCT01088815 Phase II Gemcitabine + Nab-paclitaxel + Vismodegib Hedgehog Inhibitors for Metastatic Adenocarcinoma of the Pancreas Completed
NCT01351103 Phase I LGK974 LGK974 + Spartalizumab A Study of LGK974 in Patients With Malignancies Dependent on Wnt Ligands Recruiting
NCT01383538 Phase I Fluorouracil + Irinotecan + Leucovorin + Oxaliplatin + Saridegib FOLFIRINOX Plus IPI-926 for Advanced Pancreatic Adenocarcinoma Completed
NCT01420874 Phase I EGFRBi-armed autologous activated T cells Fluorouracil + Leucovorin + Oxaliplatin + Pembrolizumab Anti-CD3 x Anti-Erbitux Armed Activated T Cells (Phase Ib) for Gastrointestinal (GI Cancer) Active, not recruiting
NCT01431794 Phase Ib/II Gemcitabine + Nab-paclitaxel + Sonidegib Gemcitabine + Nab-paclitaxel With LDE-225 (Hedgehog Inhibitor) as Neoadjuvant Therapy for Pancreatic Adenocarcinoma Active, not recruiting
NCT01473940 Phase I Gemcitabine + Ipilimumab Ipilimumab and Gemcitabine Hydrochloride in Treating Patients With Stage III-IV or Recurrent Pancreatic Cancer That Cannot Be Removed by Surgery Unknown status
NCT01485744 Phase I Fluorouracil + Irinotecan + Leucovorin + Oxaliplatin Sonidegib LDE225 With Fluorouracil, Leucovorin, Oxaliplatin, and Irinotecan for Untreated Advanced Pancreatic Cancer Active, not recruiting
NCT01488552 Phase Ib/II Oxaliplatin Fluorouracil + Irinotecan + Leucovorin Gemcitabine + Nab-paclitaxel Metformin Gemcitabine+Nab-paclitaxel and FOLFIRINOX and Molecular Profiling for Patients With Advanced Pancreatic Cancer Completed
NCT01489865 Phase Ib/II Fluorouracil + Leucovorin + Oxaliplatin + Pembrolizumab Veliparib ABT-888 With Modified FOLFOX6 in Patients With Metastatic Pancreatic Cancer Active, not recruiting
NCT01506973 Phase Ib/II Hydroxychloroquine Gemcitabine A Phase I/II/Pharmacodynamic Study of Hydroxychloroquine in Combination With Gemcitabine/Abraxane to Inhibit Autophagy in Pancreatic Cancer Active, not recruiting
NCT01555489 Phase II Assessing the Efficacy and Safety of IV Vitamin C in Combination With Standard Chemotherapy for Pancreatic Ca Terminated
NCT01576666 Phase Ib/II Buparlisib + Sonidegib Phase Ib, Dose Escalation Study of Oral LDE225 in Combination With BKM120 in Patients With Advanced Solid Tumors Completed
NCT01585805 Phase II Veliparib Cisplatin + Gemcitabine Gemcitabine Hydrochloride and Cisplatin With or Without Veliparib or Veliparib Alone in Patients With Locally Advanced or Metastatic Pancreatic Cancer Active, not recruiting
NCT01586611 Phase III Gemcitabine Fluorouracil + Leucovorin + Oxaliplatin + Pembrolizumab A Study to See if hENT1 Testing on Tumour Tissue Can Predict Response to Treatment With Gemcitabine Chemotherapy and if a Different Chemotherapy Called FOLFOX is Better Than Gemcitabine in Metastatic Pancreas Cancer Unknown status
NCT01652976 Phase II Fluorouracil + Leucovorin + Oxaliplatin + Pembrolizumab Dasatinib Phase II Study of 5-FU, Oxaliplatin Plus Dasatinib in Metastatic Pancreatic Adenocarcinoma Active, not recruiting
NCT01660971 Phase I Dasatinib + Erlotinib + Gemcitabine Gemcitabine Hydrochloride, Dasatinib, and Erlotinib Hydrochloride in Treating Patients With Metastatic Pancreatic Cancer That Cannot Be Removed By Surgery Active, not recruiting
NCT01666730 Phase II Fluorouracil + Leucovorin + Oxaliplatin + Pembrolizumab Metformin Metformin Plus Modified FOLFOX 6 in Metastatic Pancreatic Cancer Completed
NCT01683422 Phase II Capecitabine + Erlotinib + Gemcitabine Chemotherapy Plus Proton-chemotherapy for Locally Advanced Pancreatic Cancer Completed
NCT01764477 Phase I Gemcitabine + Pri-724 Safety and Efficacy Study of PRI-724 Plus Gemcitabine in Subjects With Advanced or Metastatic Pancreatic Adenocarcinoma Completed
NCT01783171 Phase I Dinaciclib + MK2206 Dinaciclib and Akt Inhibitor MK2206 in Treating Patients With Pancreatic Cancer That Cannot Be Removed By Surgery Completed
NCT01803282 Phase I GS-5745 Fluorouracil + Leucovorin + Oxaliplatin + Pembrolizumab Carboplatin + Pemetrexed Fluorouracil + Irinotecan + Leucovorin Gemcitabine + Nab-paclitaxel Carboplatin + Paclitaxel Paclitaxel Bevacizumab Safety and Tolerability Study in Solid Tumors Completed
NCT01804530 Phase I PLX7486 Gemcitabine + Nab-paclitaxel Phase 1 Study of PLX7486 as Single Agent and With Gemcitabine Plus Nab-Paclitaxel in Patients With Advanced Solid Tumors Terminated
NCT01825603 Phase I ADH-1 + Cisplatin + Gemcitabine ADH-1, Gemcitabine Hydrochloride and Cisplatin in Treating Patients With Metastatic Pancreatic or Biliary Tract Cancer That Cannot Be Removed By Surgery Completed
NCT01858883 Phase I Nab-paclitaxel Filgrastim Itacitinib Gemcitabine Safety Study of INCB039110 in Combination With Gemcitabine and Nab-Paclitaxel in Subjects With Advanced Solid Tumors Completed
NCT01896869 Phase II Fluorouracil + Irinotecan + Leucovorin + Oxaliplatin Ipilimumab A Phase 2, Multicenter Study of FOLFIRINOX Followed by Ipilimumab With Allogenic GM-CSF Transfected Pancreatic Tumor Vaccine in the Treatment of Metastatic Pancreatic Cancer Active, not recruiting
NCT01908478 Phase I Veliparib Gemcitabine A Phase I Study of Veliparib (ABT-888) in Combination With Gemcitabine and Intensity Modulated Radiation Therapy in Patients With Locally Advanced, Unresectable Pancreatic Cancer Active, not recruiting
NCT01921751 Phase II Gemcitabine + Nab-paclitaxel Capecitabine High or Standard Intensity Radiation Therapy After Gemcitabine Hydrochloride and Nab-paclitaxel in Treating Patients With Pancreatic Cancer That Cannot Be Removed by Surgery Terminated
NCT01924260 Phase I Alisertib + Gemcitabine Alisertib and Gemcitabine Hydrochloride in Treating Patients With Solid Tumors or Pancreatic Cancer Active, not recruiting
NCT01956812 Phase III Y90 clivatuzumab tetraxetan Gemcitabine Phase 3 Trial of 90Y-Clivatuzumab Tetraxetan & Gemcitabine vs Placebo & Gemcitabine in Metastatic Pancreatic Cancer (PANCRIT-1) Terminated
NCT01959672 Phase II Nelfinavir Oregovomab Fluorouracil + Leucovorin Gemcitabine Combination Chemotherapy With or Without Oregovomab Followed by Stereotactic Body Radiation Therapy and Nelfinavir Mesylate in Treating Patients With Locally Advanced Pancreatic Cancer Active, not recruiting
NCT02004262 Phase II Irinotecan Erlotinib Cyclophosphamide Capecitabine + Fluorouracil + Gemcitabine Safety and Efficacy of Combination Listeria/GVAX Pancreas Vaccine in the Pancreatic Cancer Setting Completed
NCT02005315 Phase I Gemcitabine + Nab-paclitaxel + Vantictumab A Study of Vantictumab (OMP-18R5) in Combination With Nab-Paclitaxel and Gemcitabine in Previously Untreated Stage IV Pancreatic Cancer Completed
NCT02024607 Phase Ib/II Capecitabine + Oxaliplatin Bevacizumab + Napabucasin Napabucasin + Regorafenib Fluorouracil + Leucovorin + Oxaliplatin + Pembrolizumab Napabucasin Fluorouracil + Irinotecan + Leucovorin A Study of BBI608 in Combination With Standard Chemotherapies in Adult Patients With Advanced Gastrointestinal Cancer Active, not recruiting
NCT02037230 Phase Ib/II Adavosertib + Gemcitabine Dose Escalation Trial of MK1775 and Gemcitabine (+Radiation) for Unresectable Adenocarcinoma of the Pancreas Active, not recruiting
NCT02048384 Phase Ib/II Metformin + Sirolimus Metformin A Study of Metformin With or Without Rapamycin as Maintenance Therapy After Induction Chemotherapy in Subjects With Pancreatic Cancer Active, not recruiting
NCT02077881 Phase Ib/II Indoximod Gemcitabine + Nab-paclitaxel Study of IDO Inhibitor in Combination With Gemcitabine and Nab-Paclitaxel in Patients With Metastatic Pancreatic Cancer Completed
NCT02080260 Phase II Regorafenib A Study of Regorafenib in Advanced Pancreatic Cancer Patients Completed
NCT02117479 Phase III Ruxolitinib Capecitabine Study of Ruxolitinib in Pancreatic Cancer Patients (Janus 1) Terminated
NCT02119663 Phase III Capecitabine Capecitabine + Ruxolitinib A Study of Ruxolitinib in Pancreatic Cancer Patients Terminated
NCT02138383 Phase I Enzalutamide Nab-paclitaxel Gemcitabine Enzalutamide in Combination With Gemcitabine and Nab-Paclitaxel for the Treatment of Advanced Pancreatic Cancer Active, not recruiting
NCT02153450 Phase I Metformin Stereotactic Radiosurgery and Metformin Hydrochloride in Treating Patients With Borderline-Resectable or Locally-Advanced Pancreatic Cancer Active, not recruiting
NCT02155088 Phase I Alpelisib + Gemcitabine + Nab-paclitaxel BYL719 in Combination With Gemcitabine and (Nab)-Paclitaxel in Locally Advanced and Metastatic Pancreatic Cancer Active, not recruiting
NCT02178436 Phase Ib/II Gemcitabine + Nab-paclitaxel + Selinexor Selinexor, Gemcitabine Hydrochloride, and Paclitaxel Albumin-Stabilized Nanoparticle Formulation in Treating Patients With Metastatic Pancreatic Cancer Active, not recruiting
NCT02184195 Phase III Olaparib Olaparib in gBRCA Mutated Pancreatic Cancer Whose Disease Has Not Progressed on First Line Platinum-Based Chemotherapy (POLO) Active, not recruiting
NCT02187848 Phase Ib/II SAR408701 Evaluation of SAR408701 in Patients With Advanced Solid Tumors Recruiting
NCT02194829 Phase Ib/II Paclitaxel Gemcitabine Adavosertib Paclitaxel Albumin-Stabilized Nanoparticle Formulation and Gemcitabine Hydrochloride With or Without WEE1 Inhibitor MK-1775 in Treating Patients With Previously Untreated Pancreatic Cancer That Is Metastatic or Cannot Be Removed by Surgery Active, not recruiting
NCT02227940 Phase I Ceritinib + Gemcitabine + Nab-paclitaxel Ceritinib + Cisplatin + Gemcitabine Ceritinib + Gemcitabine Ceritinib and Combination Chemotherapy in Treating Patients With Advanced Solid Tumors or Locally Advanced or Metastatic Pancreatic Cancer Active, not recruiting
NCT02231723 Phase I Gemcitabine + Nab-paclitaxel + Napabucasin A Study of BBI608 in Combination With Gemcitabine and Nab-Paclitaxel in Adult Patients With Metastatic Pancreatic Adenocarcinoma Active, not recruiting
NCT02243371 Phase II GVAX pancreatic cancer vaccine CRS-207 Cyclophosphamide GVAX Pancreas Vaccine (With CY) and CRS-207 With or Without Nivolumab Active, not recruiting
NCT02244489 Phase I Capecitabine Oxaliplatin Momelotinib Momelotinib Combined With Capecitabine and Oxaliplatin in Adults With Relapsed/Refractory Metastatic Pancreatic Ductal Adenocarcinoma Terminated
NCT02309177 Phase I Carboplatin Gemcitabine Nab-paclitaxel + Nivolumab Safety Study of Nivolumab With Nab-Paclitaxel Plus or Minus Gemcitabine in Pancreatic Cancer, Nab-Paclitaxel / Carboplatin in Stage IIIB/IV Non-Small Cell Lung Cancer or Nab-Paclitaxel in Recurrent Metastatic Breast Cancer Completed
NCT02311361 Phase I Durvalumab Tremelimumab Immune Checkpoint Inhibition (Tremelimumab and/or MEDI4736) in Combination With Radiation Therapy in Patients With Unresectable Pancreatic Cancer Recruiting
NCT02331251 Phase Ib/II Vinorelbine Pembrolizumab Irinotecan Doxorubicin Gemcitabine Docetaxel Nab-paclitaxel Study of Pembrolizumab Plus Chemotherapy in Patients With Advanced Cancer (PembroPlus) Terminated
NCT02336087 Phase I Gemcitabine + Metformin + Nab-paclitaxel Gemcitabine Hydrochloride, Paclitaxel Albumin-Stabilized Nanoparticle Formulation, Metformin Hydrochloride, and a Standardized Dietary Supplement in Treating Patients With Metastatic Pancreatic Cancer Recruiting
NCT02340117 Phase II SGT-53 Gemcitabine + Nab-paclitaxel Study of Combined SGT-53 Plus Gemcitabine/Nab-Paclitaxel for Metastatic Pancreatic Cancer Recruiting
NCT02349867 Phase I Gemcitabine + Nab-paclitaxel + Sorafenib + Vorinostat Gemcitabine Hydrochloride, Nab-Paclitaxel, Radiation Therapy, Sorafenib Tosylate,Vorinostat in Treating Previously Untreated Pancreatic Cancer Patients Recruiting
NCT02383433 Phase II Gemcitabine + Regorafenib Regorafenib Plus Gemcitabine in Metastatic Pancreatic Cancer Terminated
NCT02399137 Phase II Nab-paclitaxel Gemcitabine MM-141 A Phase 2 Study of MM-141 Plus Nab-paclitaxel and Gemcitabine in Front-line Metastatic Pancreatic Cancer Completed
NCT02403271 Phase Ib/II Durvalumab + Ibrutinib A Multi-Center Study of Ibrutinib in Combination With MEDI4736 in Subjects With Relapsed or Refractory Solid Tumors Completed
NCT02428270 Phase II GSK2256098 + Trametinib A Study of GSK2256098 and Trametinib in Advanced Pancreatic Cancer Active, not recruiting
NCT02436668 Phase II Gemcitabine + Nab-paclitaxel Ibrutinib Study of Ibrutinib vs Placebo, in Combination With Nab-paclitaxel and Gemcitabine, in the First Line Treatment of Patients With Metastatic Pancreatic Adenocarcinoma Active, not recruiting
NCT02451982 Phase Ib/II Nivolumab Cyclophosphamide + GVAX pancreatic cancer vaccine Neoadjuvant/Adjuvant GVAX Pancreas Vaccine (With CY) With or Without Nivolumab Trial for Surgically Resectable Pancreatic Cancer Recruiting
NCT02472977 Phase Ib/II Nivolumab Ulocuplumab Safety and Efficacy Study of Ulocuplumab and Nivolumab in Subjects With Solid Tumors Terminated
NCT02498613 Phase II Cediranib + Olaparib A Phase 2 Study of Cediranib in Combination With Olaparib in Advanced Solid Tumors Recruiting
NCT02540291 Phase I E7046 Study of E7046 in Subjects With Selected Advanced Malignancies Terminated
NCT02562898 Phase Ib/II Gemcitabine + Ibrutinib + Paclitaxel Ibrutinib Combined With Gemcitabine and Nab-Paclitaxel in Patients With Metastatic Pancreatic Cancer Active, not recruiting
NCT02570711 Phase II Acalabrutinib Gemcitabine + Nab-paclitaxel Study of Nab Paclitaxel/Gemcitabine Alone and in Combination With ACP-196 in Subjects With Previously Untreated Metastatic Pancreatic Cancer Terminated
NCT02574663 Phase I Gemcitabine + Nab-paclitaxel Bevacizumab Fluorouracil + Leucovorin + Oxaliplatin + Pembrolizumab Umbralisib TGR-1202 Alone and in Combination With Either Nab-paclitaxel + Gemcitabine or With FOLFOX in Patients With Select Relapsed or Refractory Solid Tumors Active, not recruiting
NCT02575508 Phase Ib/II BGJ398 + Fluorouracil + Irinotecan + Oxaliplatin Pan FGFR Kinase Inhibitor BGJ398 and Combination Chemotherapy in Treating Patients With Untreated Metastatic Pancreatic Cancer Withdrawn
NCT02608229 Phase I Gemcitabine + Nab-paclitaxel + Ulixertinib BVD-523 Plus Nab-paclitaxel and Gemcitabine in Patients With Metastatic Pancreatic Cancer Recruiting
NCT02620423 Phase I Gemcitabine Fluorouracil Irinotecan Reolysin Leucovorin Pembrolizumab Study of Pembrolizumab With REOLYSIN and Chemotherapy in Patients With Advanced Pancreatic Adenocarcinoma Completed
NCT02620800 Phase Ib/II Bevacizumab + Fluorouracil + Leucovorin + Nab-paclitaxel + Oxaliplatin Study of 5-fluorouracil (5-FU), Nab-paclitaxel, Bevacizumab, Leucovorin, and Oxaliplatin in Patients With Metastatic Pancreatic Cancer Completed
NCT02620865 Phase Ib/II Paclitaxel Aldesleukin Oxaliplatin Sargramostim Gemcitabine Fluorouracil + Leucovorin Bispecific Antibody Armed Activated T-cells With Aldesleukin and Sargramostim in Treating Patients With Locally Advanced or Metastatic Pancreatic Cancer Active, not recruiting
NCT02638909 Phase II Ceritinib Study of Oral Ceritinib in Patients With ALK-Activated Gastrointestinal Malignancies Terminated
NCT02639026 Phase I Durvalumab + Tremelimumab Trial Of Hypofractionated Radiotherapy In Combination With MEDI4736 And Tremelimumab For Patients With Metastatic Melanoma And Lung, Breast And Pancreatic Cancers Recruiting
NCT02648282 Phase II Cyclophosphamide + GVAX pancreatic cancer vaccine + Pembrolizumab Study With CY, Pembrolizumab, GVAX, and SBRT in Patients With Locally Advanced Pancreatic Cancer Recruiting
NCT02650635 Phase I Cyclophosphamide + Motolimod + Pegfilgrastim TLR8 Agonist VTX-2337 and Cyclophosphamide in Treating Patients With Metastatic, Persistent, Recurrent, or Progressive Solid Tumors Terminated
NCT02650804 Phase II BPM 31510 BPM 31510 + Gemcitabine BPM31510 Administered Intravenously With or Without Gemcitabine in Advanced Pancreatic Cancer Patients Active, not recruiting
NCT02651727 Phase I Gemcitabine + Nab-paclitaxel + VS-4718 Ph 1 Study of VS-4718, a FAK Inhibitor, in Combination With Nab-paclitaxel and Gemcitabine in Advanced Cancer Subjects Terminated
NCT02660034 Phase I BGB-A317 + Pamiparib The Safety, Pharmacokinetics and Antitumor Activity of BGB-A317 in Combination With BGB-290 in Subjects With Advanced Solid Tumors Recruiting
NCT02675946 Phase I CGX1321 Study of CGX1321 in Subjects With Advanced Solid Tumors Recruiting
NCT02677038 Phase II Olaparib Olaparib for BRCAness Phenotype in Pancreatic Cancer Recruiting
NCT02703571 Phase Ib/II Ribociclib + Trametinib Study of Safety and Efficacy of Ribociclib and Trametinib in Patients With Metastatic or Advanced Solid Tumors Recruiting
NCT02734160 Phase I Durvalumab + Galunisertib A Study of Galunisertib (LY2157299) and Durvalumab (MEDI4736) in Participants With Metastatic Pancreatic Cancer Active, not recruiting
NCT02824042 Phase I Anetumab ravtansine + Itraconazole Anetumab ravtansine Thorough ECG (Electrocardiogram) and Drug Interaction Study With Anetumab Ravtansine and Itraconazole Active, not recruiting
NCT02826486 Phase II BKT140 + Pembrolizumab BKT140 Study Assessing Safety and Efficacy of Combination of BL-8040 and Pembrolizumab in Metastatic Pancreatic Cancer Patients (COMBAT/KEYNOTE-202) (COMBAT) Recruiting
NCT02847000 Phase 0 Decitabine + Tetrahydrouridine p53/p16-Independent Epigenetic Therapy With Oral Decitabine/Tetrahydrouridine for Pancreatic Cancer Completed
NCT02868632 Phase I Tremelimumab Durvalumab + Tremelimumab Durvalumab Study of Immune Checkpoint Inhibition With Radiation Therapy in Unresectable, Non-metastatic Pancreatic Cancer Withdrawn
NCT02890355 Veliparib Fluorouracil + Irinotecan + Leucovorin FOLFIRI or Modified FOLFIRI and Veliparib as Second Line Therapy in Treating Patients With Metastatic Pancreatic Cancer Active, not recruiting
NCT02902484 Phase Ib/II Gemcitabine + Nab-paclitaxel + Nintedanib Nintedanib Study of Nintedanib and Chemotherapy for Advanced Pancreatic Cancer Recruiting
NCT02907099 Phase II BKT140 + Pembrolizumab Pembrolizumab and BL-8040 in Metastatic Pancreatic Cancer Recruiting
NCT02908451 Phase I AbGn-107 A Study of AbGn-107 in Patients With Gastric, Colorectal, or Pancreatic Cancer Recruiting
NCT02923921 Phase III Fluorouracil + Leucovorin + Oxaliplatin + Pegilodecakin Fluorouracil + Leucovorin + Oxaliplatin Study of AM0010 With FOLFOX Compared to FOLFOX Alone Second-line Tx in Pts With Metastatic Pancreatic Cancer Recruiting
NCT02985125 Phase Ib/II Everolimus + Ribociclib LEE011 Plus Everolimus in Patients With Metastatic Pancreatic Adenocarcinoma Refractory to Chemotherapy Active, not recruiting
NCT03006302 Phase II CRS-207 + Epacadostat + Pembrolizumab CRS-207 + Cyclophosphamide + Epacadostat + GVAX pancreatic cancer vaccine + Pembrolizumab Epacadostat, Pembrolizumab, and CRS-207, With or Without CY/GVAX Pancreas in Patients With Metastatic Pancreas Cancer Recruiting
NCT03086369 Phase Ib/II Gemcitabine + Nab-paclitaxel + Olaratumab Gemcitabine + Nab-paclitaxel A Study of Nab-Paclitaxel and Gemcitabine With or Without Olaratumab (LY3012207) in Participants With Metastatic Pancreatic Cancer Recruiting
NCT03086642 Phase I Talimogene laherparepvec Study of Talimogene Laherparepvec (T-VEC) in Pancreatic Cancer Recruiting
NCT03095781 Phase I Pembrolizumab + XL888 Pembrolizumab and XL888 in Patients With Advanced Gastrointestinal Cancer Recruiting
NCT03098550 Phase Ib/II Daratumumab + Nivolumab A Study to Test the Safety and Effectiveness of Nivolumab Combined With Daratumumab in Patients With Advanced Solid Tumors or Tumors That Have Spread Active, not recruiting
NCT03104439 Phase II Ipilimumab + Nivolumab Nivolumab and Ipilimumab and Radiation Therapy in MSS and MSI High Colorectal and Pancreatic Cancer Recruiting
NCT03127124 Phase Ib/II Bevacizumab + Fluorouracil + Leucovorin + NANT-008 + Oxaliplatin QUILT-2.022 NANT-008 in Combination w/ 5-fluorouracil, Bevacizumab, Leucovorin & Oxaliplatin in Subjects With Pancreatic Cancer Recruiting
NCT03140670 Phase II Rucaparib Rucaparib in BRCA1/2 or PALB2 Mutated Pancreatic Cancer Recruiting
NCT03153410 Phase I Cyclophosphamide + GVAX pancreatic cancer vaccine + LY3022855 + Pembrolizumab Pilot Study With CY, Pembrolizumab, GVAX, and IMC-CS4 (LY3022855) in Patients With Borderline Resectable Adenocarcinoma of the Pancreas Recruiting
NCT03190265 Phase II CRS-207 + Ipilimumab + Nivolumab CRS-207 + Cyclophosphamide + GVAX pancreatic cancer vaccine + Ipilimumab + Nivolumab Study of CRS-207, Nivolumab, and Ipilimumab With or Without GVAX Pancreas Vaccine (With Cy) in Patients With Pancreatic Cancer Recruiting
NCT03213626 Phase II Cabozantinib + Erlotinib Cabozantinib and Erlotinib for Patients With EGFR and c-Met Co-expressing Metastatic Pancreatic Adenocarcinoma Recruiting
NCT03214250 Phase Ib/II Gemcitabine + Nab-paclitaxel + Nivolumab APX005M + Gemcitabine + Nab-paclitaxel APX005M + Gemcitabine + Nab-paclitaxel + Nivolumab Safety and Efficacy of APX005M With Gemcitabine and Nab-Paclitaxel With or Without Nivolumab in Patients With Previously Untreated Metastatic Pancreatic Adenocarcinoma Active, not recruiting
NCT03245541 Phase Ib/II Durvalumab Study of Durvalumab and Stereotactive Ablative Body Radiotherapy in Advanced Pancreatic Adenocarcinoma (DurvaRad) Suspended
NCT03250273 Phase II Entinostat + Nivolumab A Clinical Trial of Entinostat in Combination With Nivolumab for Patients With Previously Treated Unresectable or Metastatic Cholangiocarcinoma and Pancreatic Adenocarcinoma Recruiting
NCT03261947 Phase II TAK-931 A Study to Evaluate the Safety, Tolerability, and Activity of TAK-931 in Participants With Metastatic Pancreatic Cancer, Metastatic Colorectal Cancer, and Other Advanced Solid Tumors Recruiting
NCT03277209 Phase I Plerixafor To Assess the Safety of Continuous IV Administration of Plerixafor and Assess Impact on the Immune Microenvironment in Patients With Pancreatic, Ovarian and Colorectal Adenocarcinomas Active, not recruiting
NCT03281382 Phase I Ad5-yCD/mutTKSR39rep-hIL12 Phase 1 Trial of Interleukin 12 Gene Therapy for Metastatic Pancreatic Cancer Recruiting
NCT03310632 Phase Ib/II Antroquinonol Determine Function of Antroquinonol in Combination With SOC in First Line Metastatic Pancreatic Cancer Recruiting
NCT03316599 Phase I Ficlatuzumab + Gemcitabine + Nab-paclitaxel Study of Gemcitabine, Nab-paclitaxel, and Ficlatuzumab (AV-299) in Patients With Advanced Pancreatic Cancer Recruiting
NCT03329950 Phase I CDX-1140 + CDX-301 CDX-1140 A Study of CDX-1140 as Monotherapy or in Combination in Patients With Advanced Solid Tumors Recruiting
NCT03331562 Phase II Pembrolizumab Paricalcitol + Pembrolizumab A SU2C Catalyst Trial of a PD1 Inhibitor With or Without a Vitamin D Analog for the Maintenance of Pancreatic Cancer Recruiting
NCT03336216 Phase II Cabiralizumab + Gemcitabine + Nab-paclitaxel + Nivolumab Cabiralizumab + Nivolumab Fluorouracil + Irinotecan + Leucovorin Gemcitabine + Nab-paclitaxel Cabiralizumab + Fluorouracil + Irinotecan + Leucovorin + Nivolumab A Study of Cabiralizumab Given With Nivolumab With and Without Chemotherapy in Patients With Advanced Pancreatic Cancer Recruiting
NCT03337087 Phase Ib/II Fluorouracil + Irinotecan + Leucovorin + Rucaparib Liposomal Irinotecan, Fluorouracil, Leucovorin Calcium, and Rucaparib Phosphate in Treating Patients With Metastatic Pancreatic, Colorectal, Gastroesophageal, or Biliary Cancer Recruiting
NCT03344172 Phase II Avelumab + Gemcitabine + Hydroxychloroquine + Nab-paclitaxel Gemcitabine + Hydroxychloroquine + Nab-paclitaxel Pre-Operative Trial (PGHA vs. PGH) for Resectable Pancreatic Cancer (17-134) Suspended
NCT03373188 Phase I Nivolumab + VX15/2503 Ipilimumab + VX15/2503 VX15/2503 VX15/2503 and Immunotherapy in Resectable Pancreatic and Colorectal Cancer Recruiting
NCT03374852 Phase II CPI-613 + Fluorouracil + Irinotecan + Leucovorin + Oxaliplatin CPI-613 in Combination With Modified FOLFIRINOX in Patients With Locally Advanced Pancreatic Cancer Withdrawn
NCT03376659 Phase Ib/II Capecitabine + CV301 + Durvalumab Bevacizumab + Capecitabine + CV301 + Durvalumab Durvalumab Plus CV301 With Maintenance Chemotherapy in Metastatic Colorectal or Pancreatic Adenocarcinoma Recruiting
NCT03387098 Phase Ib/II GI-4000 Leucovorin Nab-paclitaxel Bevacizumab Avelumab ALT-803 Fluorouracil ETBX-011 Oxaliplatin Aldoxorubicin Capecitabine Cyclophosphamide QUILT-3.070: Molecularly Informed Integrated Immunotherapy Combining Innate High-affinity Natural Killer (haNK) Cell Therapy With Adenoviral and Yeast-based Vaccines to Induce T-cell Responses in Subjects With Pancreatic Cancer Who Have Progressed on or After Standard-of-care Therapy Active, not recruiting
NCT03403049 Phase I Cisplatin + Gemcitabine Capecitabine + Gemcitabine Carbon Ion Radiation Therapy for Locally Advanced Pancreatic Cancer Recruiting
NCT03404960 Phase Ib/II Ipilimumab + Niraparib Niraparib + Nivolumab Niraparib + Ipilimumab or Nivolumab in Progression Free Pancreatic Adenocarcinoma After Platinum-Based Chemotherapy (Parpvax) Recruiting
NCT03432676 Phase II Epacadostat + Pembrolizumab Study of IDO-1 Inhibitor Epacadostat in Combination With Pembrolizumab in Advanced Pancreatic Cancer With Chromosomal Instability/ Homologous Recombination Repair Deficiency (HRD) Withdrawn
NCT03451773 Phase Ib/II Gemcitabine + M7824 M7824 (MSB0011359C) in Combination With Gemcitabine in Adults With Previously Treated Advanced Adenocarcinoma of the Pancreas Recruiting
NCT03490760 Phase II Durvalumab Durvalumab and "Booster" Radiation in Metastatic Adenocarcinoma of the Pancreas Recruiting
NCT03519308 Phase I Gemcitabine + Nab-paclitaxel + Nivolumab + Paricalcitol Gemcitabine + Nab-paclitaxel + Nivolumab A Pilot Study of Perioperative Nivolumab and Paricalcitol to Target the Micoenvironment in Resectable Pancreatic Cancer Recruiting
NCT03553004 Phase II Niraparib Niraparib in Metastatic Pancreatic Cancer After Previous Chemotherapy (NIRA-PANC): a Phase 2 Trial Recruiting
NCT03563144 Phase II Gemcitabine Gemcitabine + Nab-paclitaxel Aldoxorubicin + ALT-803 + Avelumab + Bevacizumab + Capecitabine + Cyclophosphamide + ETBX-011 + ETBX-021 + ETBX-051 + ETBX-061 + Fluorouracil + Gemcitabine + GI-4000 + GI-6207 + GI-6301 + haNK cells + Leucovorin + Nab-paclitaxel + Oxaliplatin QUILT-3.088: NANT Pancreatic Cancer Vaccine Not yet recruiting
NCT03563248 Phase II Fluorouracil + Irinotecan + Leucovorin + Oxaliplatin Fluorouracil + Irinotecan + Leucovorin + Losartan + Oxaliplatin Fluorouracil + Irinotecan + Leucovorin + Losartan + Nivolumab + Oxaliplatin Fluorouracil + Irinotecan + Leucovorin + Nivolumab + Oxaliplatin Losartan and Nivolumab in Combination With FOLFIRINOX and SBRT in Localized Pancreatic Cancer Recruiting
NCT03586869 Phase Ib/II Aldoxorubicin + ALT-803 + Avelumab + Bevacizumab + Capecitabine + Cyclophosphamide + ETBX-011 + ETBX-021 + ETBX-051 + ETBX-061 + Fluorouracil + Gemcitabine + GI-4000 + GI-6207 + GI-6301 + haNK cells + Leucovorin + Nab-paclitaxel + Oxaliplatin QUILT-3.080: NANT Pancreatic Cancer Vaccine Active, not recruiting
NCT03601923 Phase II Niraparib Niraparib in Patients With Pancreatic Cancer Recruiting
NCT03611556 Phase Ib/II Gemcitabine + Nab-paclitaxel + Oleclumab Durvalumab + Gemcitabine + Nab-paclitaxel + Oleclumab Fluorouracil + Leucovorin + Oxaliplatin Fluorouracil + Leucovorin + Oleclumab + Oxaliplatin Durvalumab + Fluorouracil + Leucovorin + Oleclumab + Oxaliplatin MEDI9447(Oleclumab) Pancreatic Chemotherapy Combination Study Recruiting
NCT03649321 Phase Ib/II Cisplatin + Gemcitabine + Nab-paclitaxel BGB-324 + Cisplatin + Gemcitabine + Nab-paclitaxel Chemotherapy With Nab-paclitaxel/Germcitabine/Cisplatin +/- BGB324 With Pancreatic Cancer Recruiting
NCT03697564 FDA approved Cabiralizumab + Gemcitabine + Nivolumab Gemcitabine Nivolumab + Cabiralizumab + Gemcitabine Versus Gemcitabine in Patients With Stage IV Pancreatic Cancer Achieving Disease Control in Response to First-line Chemotherapy (GemCaN Trial). Not yet recruiting
NCT03723915 Phase II Pembrolizumab + Reolysin Pembrolizumab and Pelareorep in Treating Patients With Advanced Pancreatic Cancer Recruiting
NCT03767582 Phase Ib/II BMS-813160 + GVAX pancreatic cancer vaccine + Nivolumab BMS-813160 + Nivolumab Trial of Neoadjuvant and Adjuvant Nivolumab and BMS-813160 With or Without GVAX for Locally Advanced Pancreatic Ductal Adenocarcinomas. Not yet recruiting
NCT03801915 Phase II MVT-5873 Perioperative MVT-5873, a Fully Human Monoclonal Antibody Against a CA 19-9 Epitope, for Operable CA 19-9 Producing Pancreatic Cancers, Cholangiocarcinomas, and Metastatic Colorectal Cancers Not yet recruiting
NCT03816163 Phase II Gemcitabine + Nab-paclitaxel Claudiximab + Gemcitabine + Nab-paclitaxel A Study to Assess the Antitumor Activity and Safety of IMAB362 in Combination With Nab-Paclitaxel and Gemcitabine (Nab-P + GEM) as First Line Treatment in Subjects With Claudin 18.2 (CLDN18.2) Positive, Metastatic Pancreatic Adenocarcinoma Recruiting
NCT03821935 Phase I ABBV-151 ABBV-151 + ABBV-181 Study to Determine the Safety, Tolerability, Pharmacokinetics and RP2D of ABBV-151 as a Single Agent and in Combination With ABBV-181 in Subjects With Locally Advanced or Metastatic Solid Tumors Recruiting
NCT03851614 Phase II Cediranib + Durvalumab Durvalumab + Olaparib Basket Combination Study of Inhibitors of DNA Damage Response, Angiogenesis and Programmed Death Ligand 1 in Patients With Advanced Solid Tumors (DAPPER) Recruiting
NCT03891979 FDA approved Ciprofloxacin Metronidazole Pembrolizumab Gut Microbiome Modulation to Enable Efficacy of Checkpoint-based Immunotherapy in Pancreatic Adenocarcinoma Not yet recruiting
NCT03956056 Phase I Neoantigen peptide vaccine + Poly ICLC Neoantigen Peptide Vaccine Strategy in Pancreatic Cancer Patients Following Surgical Resection and Adjuvant Chemotherapy Not yet recruiting
NCT03970252 Phase Ib/II Fluorouracil + Irinotecan + Leucovorin + Oxaliplatin Fluorouracil + Irinotecan + Leucovorin + Nivolumab + Oxaliplatin Nivolumab in Combination With Chemotherapy Before Surgery in Treating Patients With Borderline Resectable Pancreatic Cancer Not yet recruiting