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|Therapy Name||EndoTAG-1 + Gemcitabine|
|Drug Name||Trade Name||Synonyms||Drug Classes||Drug Description|
|EndoTAG-1||LipoPac|MBT-0206|Cationic Liposome-Encapsulated Paclitaxel||EndoTAG-1 is comprised of paclitaxel encapsulated in cationic liposomes that preferentially targets endothelial cells, which inhibits microtubule disassembly, potentially leading to decreased cell proliferation and increased apoptosis (NCI Drug Dictionary).|
|Gemcitabine||Gemzar||Difluorodeoxycytidine Hydrochlorothiazide|LY-188011||Chemotherapy - Antimetabolite 14||Gemzar (gemcitabine) is converted in cells to difluorodeoxycytidine di- and triphosphate (dFdCDP, dFdCTP), which act to inhibit ribonucleoside reductase and as a deoxynucleotide analog respectively, resulting in DNA strand termination and apoptosis (NCI Drug Dictionary).|
|Molecular Profile||Indication/Tumor Type||Response Type||Therapy Name||Approval Status||Evidence Type||Efficacy Evidence||References|
|Clinical Trial||Phase||Therapies||Title||Recruitment Status||Covered Countries||Other Countries|
|NCT03126435||Phase III||EndoTAG-1 + Gemcitabine Gemcitabine||EndoTAG-1 Plus Gemcitabine Versus Gemcitabine Alone in Patients With Measurable Locally Advanced and/or Metastatic Adenocarcinoma of the Pancreas Failed on FOLFIRINOX Treatment||Completed||USA | FRA||5|