Therapy Detail

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Therapy Name CEP-11981
Synonyms
Therapy Description

CEP-11981 is a multikinase inhibitor that targets VEGFR1-3 and TIE2, which may inhibit tumor angiogenesis and lead to tumor growth inhibition (PMID: 24982343, PMID: 25152243).

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Drug Name Trade Name Synonyms Drug Classes Drug Description
CEP-11981 ESK981|CEP11981|CEP 11981 TIE2 Inhibitor 3 VEGFR Inhibitor (Pan) 36 CEP-11981 is a multikinase inhibitor that targets VEGFR1-3 and TIE2, which may inhibit tumor angiogenesis and lead to tumor growth inhibition (PMID: 24982343, PMID: 25152243).

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column. Be sure to set ascending or descending order for a given column before moving on to the next column.

Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column. Be sure to set ascending or descending order for a given column before moving on to the next column.

Clinical Trial Phase Therapies Title Recruitment Status Covered Countries Other Countries
NCT03562507 Phase II CEP-11981 CEP-11981 + Nivolumab Phase 2 Multi-center Trial of ESK981 in Combination With Nivolumab in Patients With Metastatic Renal Cell Carcinoma Terminated USA 0
NCT03456804 Phase II CEP-11981 ESK981 in Treating Patients With Metastatic Castrate-Resistant Prostate Cancer Completed USA 0


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