Therapy Detail

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Therapy Name BPM 31510
Synonyms
Therapy Description

BPM 31510 is a small molecule agent containing a formulation of co-enzyme Q10, thereby affecting metabolism via Warburg effect reversal and thus, potentially resulting in apoptotic activity of cancer cells (Cancer Res 2014;74(19 Suppl):Abstract nr 4321).

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Drug Name Trade Name Synonyms Drug Classes Drug Description
BPM 31510 BPM31510 BPM 31510 is a small molecule agent containing a formulation of co-enzyme Q10, thereby affecting metabolism via Warburg effect reversal and thus, potentially resulting in apoptotic activity of cancer cells (Cancer Res 2014;74(19 Suppl):Abstract nr 4321).

Filtering

  • Case insensitive filtering will display rows where any text in any cell matches the filter term
  • Simple literal full or partial string matches
  • Separate multiple filter terms with a spaces, order doesn't matter (a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page, filtering has no impact on query parameters
  • Use quotes to match a longer phrase which contains spaces "mtor c1483f"

Sorting

  • Generally, the default sort order for tables is set to be first column ascending, however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column, be sure to set ascending or descending order for a given column, before moving on to the next column.

Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
Unknown unknown triple-receptor negative breast cancer not applicable BPM 31510 Preclinical - Cell line xenograft Actionable In a preclinical study, TNBC cell lines demonstrated decreased cell viability and increased apoptotic activity in culture when treated with BPM 31510, and in cell line xenograft models, treatment resulted in reduced tumor size (Cancer Res 2016;76(14 Suppl):Abstract nr 208). detail...

Filtering

  • Case insensitive filtering will display rows where any text in any cell matches the filter term
  • Simple literal full or partial string matches
  • Separate multiple filter terms with a spaces, order doesn't matter (a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page, filtering has no impact on query parameters
  • Use quotes to match a longer phrase which contains spaces "mtor c1483f"

Sorting

  • Generally, the default sort order for tables is set to be first column ascending, however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column, be sure to set ascending or descending order for a given column, before moving on to the next column.

Clinical Trial Phase Therapies Title Recruitment Status
NCT02650804 Phase II BPM 31510 BPM 31510 + Gemcitabine BPM31510 Administered Intravenously With or Without Gemcitabine in Advanced Pancreatic Cancer Patients Completed


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