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Therapy Name ABBV-151 + Budigalimab
Synonyms
Therapy Description

Limited information is currently available on ABBV-151 (Feb, 2019).

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Drug Name Trade Name Synonyms Drug Classes Drug Description
ABBV-151 ARGX-115|ABBV151|ABBV 151|ARGX 115|ARGX-115|ARGX115|Livmoniplimab ABBV-151 is a monoclonal antibody that targets the glycoprotein A repetitions predominant (GARP)-transforming growth factor beta 1 (TGFbeta1) complex, which prevents release of active TGF-beta1, potentially leading to antitumor activity (Journal for ImmunoTherapy of Cancer 2022;10).
Budigalimab ABBV181|ABBV 181|ABBV-181 Immune Checkpoint Inhibitor 147 PD-L1/PD-1 antibody 117 Budigalimab is a monoclonal antibody that targets PD-1 (PDCD1) and inhibits binding of the PD-L1 (CD274) ligand, potentially resulting in enhanced anti-tumor immune response (PMID: 32770720).

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
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Clinical Trial Phase Therapies Title Recruitment Status Covered Countries Other Countries
NCT03821935 Phase I ABBV-151 ABBV-151 + Budigalimab Study to Determine the Safety, Tolerability, Pharmacokinetics and RP2D of ABBV-151 as a Single Agent and in Combination With ABBV-181 in Participants With Locally Advanced or Metastatic Solid Tumors Recruiting USA | FRA | ESP | CAN | BEL | AUS 5
NCT05822752 Phase II Lenvatinib Sorafenib ABBV-151 + Budigalimab Study to Evaluate Adverse Events, and Change in Disease Activity, When Intravenously (IV) Infused With Livmoniplimab in Combination With IV Infused Budigalimab in Adult Participants With Hepatocellular Carcinoma (HCC) Recruiting USA | ITA | FRA | ESP 3
NCT06109272 Phase II ABBV-151 + Budigalimab Atezolizumab + Bevacizumab Durvalumab + Tremelimumab A Study to Assess the Dose, Adverse Events, and Change in Disease Activity of Livmoniplimab as an Intravenous (IV) Solution in Combination With Budigalimab as an IV Solution in Adult Participants With Hepatocellular Carcinoma (HCC) (LIVIGNO-2) Recruiting USA | ESP 1


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