Therapy Detail

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Therapy Name AdV-tk + Valacyclovir
Synonyms
Therapy Description

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Drug Name Trade Name Synonyms Drug Classes Drug Description
AdV-tk Aglatimagene besadenovec|GliAtak|ProstAtak|CAN-2409|CAN2409|Virafir ADV-tk (aglatimagene besadenovec) is an engineered adenoviral vector expressing the herpes simplex virus thymidine kinase that sensitizes tumor cells to therapy with acyclic guanosine analogues (PMID: 26843484, PMID: 30883662).
Valacyclovir Valtrex Acicloftal Valacyclovir is the prodrug of acyclovir, which is an antiviral agent that functions by inhibiting viral DNA polymerase (NCI Drug Dictionary).

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column. Be sure to set ascending or descending order for a given column before moving on to the next column.

Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column. Be sure to set ascending or descending order for a given column before moving on to the next column.

Clinical Trial Phase Therapies Title Recruitment Status Covered Countries Other Countries
NCT03131037 Phase I AdV-tk + Valacyclovir Intratumoral Gene Mediated Cytotoxic Immunotherapy in Patients With Resectable Non-Small Cell Lung Cancer Active, not recruiting USA 0
NCT01436968 Phase III Valacyclovir AdV-tk + Valacyclovir Phase 3 Study of ProstAtak Immunotherapy With Standard Radiation Therapy for Localized Prostate Cancer Active, not recruiting USA 1
NCT01913106 Phase Ib/II AdV-tk + Valacyclovir HSV-tk + Valacyclovir Therapy in Combination With Brachytherapy for Recurrent Prostate Cancer Recruiting USA 0
NCT02768363 Phase II AdV-tk + Valacyclovir Valacyclovir Randomized Controlled Trial of ProstAtak Immunotherapy During Active Surveillance for Prostate Cancer (ULYSSES) Active, not recruiting USA 1
NCT03004183 Phase II Pembrolizumab AdV-tk + Valacyclovir SBRT and Oncolytic Virus Therapy Before Pembrolizumab for Metastatic TNBC and NSCLC (STOMP) Active, not recruiting USA 0
NCT02446093 Phase II AdV-tk + Valacyclovir Acyclovir + AdV-tk Neoadjuvant CAN-2409 in Combination With Chemoradiation or SBRT for Borderline Resectable Pancreatic Adenocarcinoma (PaTK02) Active, not recruiting USA 1


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