Therapy Detail

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Therapy Name EGFRBi-armed autologous activated T cells
Synonyms
Therapy Description

EGFRBi-armed autologous activated T cells are autologous T-cells that have been "armed" with a bispecific antibody that binds EGFR and CD3, potentially enhancing T-cell mediated response to EGFR-expressing cells upon antibody binding (NCI Drug Dictionary).

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Drug Name Trade Name Synonyms Drug Classes Drug Description
EGFRBi-armed autologous activated T cells EGFR Antibody 39 EGFRBi-armed autologous activated T cells are autologous T-cells that have been armed with a bispecific antibody that binds EGFR and CD3, potentially enhancing T-cell mediated response to EGFR-expressing cells upon antibody binding (NCI Drug Dictionary).

Filtering

  • Case insensitive filtering will display rows where any text in any cell matches the filter term
  • Simple literal full or partial string matches
  • Separate multiple filter terms with a spaces, order doesn't matter (a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page, filtering has no impact on query parameters
  • Use quotes to match a longer phrase which contains spaces "mtor c1483f"

Sorting

  • Generally, the default sort order for tables is set to be first column ascending, however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column, be sure to set ascending or descending order for a given column, before moving on to the next column.

Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References

Filtering

  • Case insensitive filtering will display rows where any text in any cell matches the filter term
  • Simple literal full or partial string matches
  • Separate multiple filter terms with a spaces, order doesn't matter (a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page, filtering has no impact on query parameters
  • Use quotes to match a longer phrase which contains spaces "mtor c1483f"

Sorting

  • Generally, the default sort order for tables is set to be first column ascending, however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column, be sure to set ascending or descending order for a given column, before moving on to the next column.

Clinical Trial Phase Therapies Title Recruitment Status Covered Countries Other Countries
NCT04137536 Phase I EGFRBi-armed autologous activated T cells A Study of Armed, Activated T-Cells in Patients With Advanced Pancreatic Cancer Active, not recruiting USA 0
NCT01081808 Phase I EGFRBi-armed autologous activated T cells Laboratory-Treated Autologous Lymphocytes, Aldesleukin, and Sargramostim (GM-CSF) in Treating Advanced Solid Tumors Terminated USA 0
NCT03344250 Phase I EGFRBi-armed autologous activated T cells Phase I EGFR BATs in Newly Diagnosed Glioblastoma Active, not recruiting USA 0
NCT03269526 Phase Ib/II EGFRBi-armed autologous activated T cells BATs Treatment for Pancreatic Cancer, Phase Ib/II Recruiting USA 0
NCT02521090 Phase Ib/II EGFRBi-armed autologous activated T cells EGFRBi-Armed Autologous T Cells in Treating Patients With Recurrent or Refractory Glioblastoma Withdrawn 0
NCT01420874 Phase I EGFRBi-armed autologous activated T cells Fluorouracil + Leucovorin + Oxaliplatin + Pembrolizumab Anti-CD3 x Anti-Erbitux Armed Activated T Cells (Phase Ib) for Gastrointestinal (GI Cancer) Completed USA 0


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