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Therapy Name Patritumab deruxtecan
Synonyms
Therapy Description

Patritumab deruxtecan (U3-1402) is an antibody-drug conjugate (ADC) comprising an ERBB3 (HER3) antibody and Exatecan, which once internalized may result in apoptotic cell death (PMID: 31395690, PMID: 31661465, PMID: 31471314).

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Drug Name Trade Name Synonyms Drug Classes Drug Description
Patritumab deruxtecan U3-1402|HER3-DXd|U3 1402|U31402 HER3 (ERBB3) Antibody 23 Patritumab deruxtecan (U3-1402) is an antibody-drug conjugate (ADC) comprising an ERBB3 (HER3) antibody and Exatecan, which once internalized may result in apoptotic cell death (PMID: 31395690, PMID: 31661465, PMID: 31471314).

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References

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Clinical Trial Phase Therapies Title Recruitment Status Covered Countries Other Countries
NCT03260491 Phase I Patritumab deruxtecan U3-1402 in Metastatic or Unresectable Non-Small Cell Lung Cancer Active, not recruiting USA | ESP 4
NCT05338970 Phase III Patritumab deruxtecan HERTHENA-Lung02: A Study of Patritumab Deruxtecan Versus Platinum-based Chemotherapy in Metastatic or Locally Advanced EGFRm NSCLC After Failure of EGFR TKI Therapy Recruiting USA | ITA | GBR | FRA | ESP | DEU | CAN | BEL | AUT | AUS 11
NCT02980341 Phase Ib/II Patritumab deruxtecan Phase I/II Study of U3-1402 in Subjects With Human Epidermal Growth Factor Receptor 3 (HER3) Positive Metastatic Breast Cancer Active, not recruiting USA 1
NCT05620914 Phase I Patritumab deruxtecan A Window of Opportunity Study of Patritumab Deruxtecan in Patients With Brain Metastases (PARAMETer) Not yet recruiting USA 0
NCT04676477 Phase I Patritumab deruxtecan Osimertinib + Patritumab deruxtecan HER3-DXd (Patritumab Deruxtecan; U3-1402) in Combination With Osimertinib in Subjects With Locally Advanced or Metastatic EGFR-mutated Non-Small Cell Lung Cancer Recruiting USA 3
NCT04699630 Phase II Patritumab deruxtecan A Study of U3-1402 (Patritumab Deruxtecan) in Subjects With Metastatic Breast Cancer Recruiting USA 0
NCT04619004 Phase II Patritumab deruxtecan HERTHENA-Lung01: Patritumab Deruxtecan in Subjects With Metastatic or Locally Advanced EGFR-mutated Non-Small Cell Lung Cancer Active, not recruiting USA | ITA | GBR | FRA | ESP | DEU | BEL | AUT | AUS 7
NCT04479436 Phase II Patritumab deruxtecan A Study to Evaluate U3-1402 in Subjects With Advanced or Metastatic Colorectal Cancer Terminated USA | ITA | GBR | FRA | ESP | BEL 2
NCT04610528 Phase I Patritumab deruxtecan A Window-of-opportunity Study of U3-1402, a HER3-targeting Antibody-drug Conjugate in Operable Breast Cancer According to ERBB3 Expression (TOT-HER3) Active, not recruiting ESP 0
NCT04965766 Phase II Patritumab deruxtecan Patritumab Deruxtecan (U3-1402) in Unresectable Locally Advanced or Metastatic Breast Cancer (ICARUS-BREAST) Recruiting FRA 0
NCT05569811 Phase II Letrozole + Patritumab deruxtecan Patritumab deruxtecan NeoadjuVAnt muLti-agENT Chemotherapy or Patritumab Deruxtecan With or Without endocrINE Therapy for High-risk HR+/HER2- Breast Cancer - VALENTINE Trial (VALENTINE) Active, not recruiting ESP 0


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