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Therapy Name BAY2287411
Synonyms
Therapy Description

BAY2287411 is a radioimmunoconjugate consisting of the radionuclide thorium-227 linked to the mesothelin (MSLN) targeting antibody BAY 86-1903 (anetumab), which induces DNA damage and cell cycle arrest, potentially resulting in increased apoptosis, reduced cell viability, and inhibition of tumor growth (PMID: 31064781).

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Drug Name Trade Name Synonyms Drug Classes Drug Description
BAY2287411 BAY-2287411|BAY 2287411|Th 227 Anetumab MSLN Antibody 10 BAY2287411 is a radioimmunoconjugate consisting of the radionuclide thorium-227 linked to the mesothelin (MSLN) targeting antibody BAY 86-1903 (anetumab), which induces DNA damage and cell cycle arrest, potentially resulting in increased apoptosis, reduced cell viability, and inhibition of tumor growth (PMID: 31064781).

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References

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  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

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Clinical Trial Phase Therapies Title Recruitment Status Covered Countries Other Countries
NCT03507452 Phase I BAY2287411 First-in-human Study of BAY2287411 Injection, a Thorium-227 Labeled Antibody-chelator Conjugate, in Patients With Tumors Known to Express Mesothelin Completed USA | NLD | GBR 2


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