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Therapy Name SAR408701
Synonyms
Therapy Description

SAR408701 is an anti-CEACAM5 antibody in conjugation with DM4, which may lead to specific toxicity towards CEACAM5-expressing tumor cells (Eu J Cancer Dec 2016, 69(Suppl 1):S14-S15).

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Drug Name Trade Name Synonyms Drug Classes Drug Description
SAR408701 SAR-408701|Tusamitamab ravtansine CEACAM5 Antibody 7 SAR408701 is an anti-CEACAM5 antibody in conjugation with DM4, which may lead to specific toxicity towards CEACAM5-expressing tumor cells (Eu J Cancer Dec 2016, 69(Suppl 1):S14-S15).

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  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References

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Clinical Trial Phase Therapies Title Recruitment Status Covered Countries Other Countries
NCT04154956 Phase III SAR408701 Docetaxel SAR408701 Versus Docetaxel in Previously Treated, Carcinoembryonic Antigen-related Cell Adhesion Molecule 5 (CEACAM5) Positive Metastatic Non-squamous Non-small-cell Lung Cancer Patients (CARMEN-LC03) Active, not recruiting USA | NLD | ITA | GBR | FRA | ESP | DEU | CAN | BEL | AUS 19
NCT05703555 Phase II SAR408701 INTRUSION: Unraveling the INTRatUmoral PK/PD relatION for SAR408701 (INTRUSION) Withdrawn NLD 0
NCT04659603 Phase II SAR408701 Gemcitabine + SAR408701 Tusamitamab Ravtansine Monotherapy and in Combination in Patients With CEACAM5-positive Advanced Solid Tumors (CARMEN-BT01) Active, not recruiting USA | NLD | ESP 7
NCT05429762 Phase I SAR408701 Effect of Tusamitamab Ravtansine on QTc Interval in Participants With Metastatic Solid Tumors (TusaRav-QT) Terminated USA | FRA | ESP | BEL 1
NCT02187848 Phase Ib/II SAR408701 Evaluation of SAR408701 in Patients With Advanced Solid Tumors Active, not recruiting USA | FRA | ESP | CAN 1
NCT05245071 Phase II SAR408701 Tusamitamab Ravtansine in NSQ NSCLC Participants With Negative or Moderate CEACAM5 Expression Tumors and High Circulating CEA (CARMEN-LC06) Active, not recruiting USA | ITA | FRA | ESP | BEL 2


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