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ID DOID:11054
Name urinary bladder cancer
Definition An urinary system cancer that results_in malignant growth located_in the urinary bladder.
Source DiseaseOntology.org
Alt Ids DOID:5428
Path disease disease of cellular proliferation cancer organ system cancer urinary system cancer urinary bladder cancer

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Molecular Profile Therapy Indication/Tumor Type Response Type Profile Response Detail
Unknown unknown PD-0325901 + PF-04691502 urinary bladder cancer not applicable detail...
FGFR3 Y375C Ponatinib urinary bladder cancer sensitive detail...
FGFR3 Y375C Dovitinib urinary bladder cancer sensitive detail...
FGFR3 Y375C Cediranib urinary bladder cancer resistant detail...
FGFR3 Y375C Nintedanib urinary bladder cancer resistant detail...
FGFR3 Y375C Brivanib urinary bladder cancer no benefit detail...
FGFR3 S249C Ponatinib urinary bladder cancer sensitive detail...
FGFR3 S249C Dovitinib urinary bladder cancer sensitive detail...
FGFR3 S249C Cediranib urinary bladder cancer sensitive detail...
FGFR3 S249C Nintedanib urinary bladder cancer resistant detail...
FGFR3 S249C Brivanib urinary bladder cancer no benefit detail...
FGFR3 wild-type Ponatinib urinary bladder cancer resistant detail...
AKT1 E17K FGFR3 Y373C AZD4547 + Capivasertib urinary bladder cancer sensitive detail...
FGFR3 - TACC3 R3Mab urinary bladder cancer sensitive detail...
FGFR3 act mut S-49076 urinary bladder cancer predicted - sensitive detail...
FGFR3 over exp SU5402 urinary bladder cancer sensitive detail...
FGFR3 - TACC3 Selumetinib urinary bladder cancer no benefit detail...
FGFR3 - TACC3 Pazopanib urinary bladder cancer sensitive detail...
FGFR3 - TACC3 LY2874455 urinary bladder cancer sensitive detail...
FGFR3 - TACC3 S-49076 urinary bladder cancer predicted - sensitive detail...
FGFR3 - TACC3 Debio 1347 urinary bladder cancer sensitive detail...
FGFR3 - BAIAP2L1 Debio 1347 urinary bladder cancer sensitive detail...
FGFR3 S249C Debio 1347 urinary bladder cancer sensitive detail...
FGFR3 - TACC3 SU5402 urinary bladder cancer sensitive detail...
FGFR3 - TACC3 AZ8010 urinary bladder cancer sensitive detail...
FGFR3 - TACC3 Dovitinib urinary bladder cancer sensitive detail...
FGFR3 - TACC3 FIIN-1 urinary bladder cancer sensitive detail...
FGFR3 - TACC3 PRN1109 urinary bladder cancer sensitive detail...
FGFR3 S249C ASP5878 urinary bladder cancer sensitive detail...
FGFR3 - TACC3 ASP5878 urinary bladder cancer sensitive detail...
FGFR3 - BAIAP2L1 ASP5878 urinary bladder cancer sensitive detail...
HRAS mutant Metformin urinary bladder cancer sensitive detail...
Unknown unknown GSK2126458 urinary bladder cancer not applicable detail...
ERBB2 amp Afatinib urinary bladder cancer sensitive detail...
Unknown unknown AZD4547 + Cisplatin + Gemcitabine urinary bladder cancer not applicable detail...
FGFR3 mut FGFR3 over exp Dovitinib urinary bladder cancer sensitive detail...
FGFR3 over exp Dovitinib urinary bladder cancer sensitive detail...
Unknown unknown ASP5878 urinary bladder cancer not applicable detail...
ERBB2 S310F Afatinib urinary bladder cancer sensitive detail...
ERBB2 S310F Lapatinib urinary bladder cancer sensitive detail...
ERBB2 S310F Selumetinib urinary bladder cancer decreased response detail...
ERBB2 S653C Afatinib urinary bladder cancer sensitive detail...
ERBB2 S653C Lapatinib urinary bladder cancer sensitive detail...
ERBB2 S653C Selumetinib urinary bladder cancer decreased response detail...
ERBB2 D277H ERBB2 S310F Afatinib urinary bladder cancer sensitive detail...
ERBB2 D277H ERBB2 S310F Lapatinib urinary bladder cancer sensitive detail...
ERBB2 D277H ERBB2 S310F Selumetinib urinary bladder cancer decreased response detail...
FGFR3 over exp Infigratinib urinary bladder cancer sensitive detail...
FGFR3 over exp Dactolisib + Sorafenib urinary bladder cancer sensitive detail...
PIK3CA H1047R Dactolisib urinary bladder cancer sensitive detail...
ERBB2 over exp PIK3CA H1047R SRC over exp Lapatinib urinary bladder cancer no benefit detail...
ERBB2 over exp PIK3CA H1047R SRC over exp Ponatinib urinary bladder cancer no benefit detail...
Unknown unknown OBP-801 urinary bladder cancer not applicable detail...
Unknown unknown Celecoxib urinary bladder cancer not applicable detail...
Unknown unknown Celecoxib + OBP-801 urinary bladder cancer not applicable detail...
FGFR3 - BAIAP2L1 PD173074 urinary bladder cancer sensitive detail...
FGFR3 - BAIAP2L1 AZD4547 urinary bladder cancer sensitive detail...
FGFR3 - BAIAP2L1 Infigratinib urinary bladder cancer sensitive detail...
FGFR3 - BAIAP2L1 Cediranib urinary bladder cancer sensitive detail...
FGFR3 - BAIAP2L1 Dovitinib urinary bladder cancer sensitive detail...
FGFR3 mutant AZD4547 urinary bladder cancer sensitive detail...
FGFR3 fusion AZD4547 urinary bladder cancer sensitive detail...
FGFR3 - TACC3 E7090 urinary bladder cancer sensitive detail...
HRAS G12V Binimetinib + Everolimus urinary bladder cancer sensitive detail...
HRAS G12V Everolimus + Selumetinib urinary bladder cancer sensitive detail...
Unknown unknown Atezolizumab urinary bladder cancer no benefit detail...
Unknown unknown Futibatinib urinary bladder cancer not applicable detail...
PIK3CA E545K Pictilisib urinary bladder cancer sensitive detail...
PIK3CA H1047R Pictilisib urinary bladder cancer sensitive detail...
PIK3CA D549Y Pictilisib urinary bladder cancer decreased response detail...
PIK3CA E545K Cisplatin + Pictilisib urinary bladder cancer sensitive detail...
PIK3CA H1047R Cisplatin + Pictilisib urinary bladder cancer sensitive detail...
PIK3CA E545K Gemcitabine + Pictilisib urinary bladder cancer sensitive detail...
PIK3CA amp Gemcitabine + Pictilisib urinary bladder cancer sensitive detail...
PIK3CA E545K Pictilisib + Sorafenib urinary bladder cancer sensitive detail...
Unknown unknown BMS-986205 + Nivolumab urinary bladder cancer not applicable detail...
ERBB2 mutant Neratinib urinary bladder cancer no benefit detail...
ERBB2 D277G ERBB2 S310F Neratinib urinary bladder cancer predicted - resistant detail...
ERBB2 D769Y Neratinib urinary bladder cancer predicted - resistant detail...
ERBB2 G292R Neratinib urinary bladder cancer predicted - resistant detail...
ERBB2 S310F Neratinib urinary bladder cancer no benefit detail...
ERBB2 S310Y Neratinib urinary bladder cancer no benefit detail...
ERBB2 V777L Neratinib urinary bladder cancer predicted - sensitive detail...
ERBB2 L755S ERBB2 V777L ERBB2 R1153* Neratinib urinary bladder cancer no benefit detail...
ERBB2 Y772_A775dup Neratinib urinary bladder cancer predicted - resistant detail...
FGFR3 K652E Derazantinib urinary bladder cancer sensitive detail...
FGFR3 - TACC3 Derazantinib urinary bladder cancer sensitive detail...
FGFR3 - BAIAP2L1 Derazantinib urinary bladder cancer sensitive detail...
Unknown unknown Camrelizumab urinary bladder cancer not applicable detail...
Unknown unknown MPT0L145 urinary bladder cancer not applicable detail...
Unknown unknown BC-819 + BCG solution urinary bladder cancer not applicable detail...
Unknown unknown CG0070 urinary bladder cancer not applicable detail...
ERBB2 amp Pertuzumab + Trastuzumab urinary bladder cancer predicted - sensitive detail...
ERBB2 over exp Pertuzumab + Trastuzumab urinary bladder cancer predicted - sensitive detail...
FGFR3 - TACC3 ODM-203 urinary bladder cancer sensitive detail...
FGFR3 - TACC3 Erdafitinib urinary bladder cancer predicted - sensitive detail...
FGFR3 - TACC3 Infigratinib urinary bladder cancer predicted - sensitive detail...
ERBB2 S310F Trastuzumab urinary bladder cancer no benefit detail...
ERBB2 S310F Pertuzumab urinary bladder cancer no benefit detail...
ERBB2 S310F Cetuximab urinary bladder cancer sensitive detail...
ERBB2 S310F Gefitinib urinary bladder cancer sensitive detail...
Unknown unknown E7766 urinary bladder cancer not applicable detail...
FGFR3 - TACC3 BO-264 urinary bladder cancer sensitive detail...
Unknown unknown Etomoxir urinary bladder cancer not applicable detail...
Clinical Trial Phase Therapies Title Recruitment Status
NCT00313599 Phase I Lapatinib + Paclitaxel Lapatinib and Paclitaxel in Treating Patients With Advanced Solid Tumors Completed
NCT00959868 Phase I Apatorsen A Study for Treatment of Superficial Bladder Cancer Using OGX-427 Unknown status
NCT01730118 Phase I HER2 Vaccine Ad/HER2/Neu Dendritic Cell Cancer Vaccine Testing Completed
NCT01738815 Phase I Valproic acid Impact of Valproate on Angiogenesis and Histone Deacetylation in Bladder Cancer Unknown status
NCT01928394 Phase Ib/II Ipilimumab + Nivolumab Cobimetinib + Ipilimumab + Nivolumab Nivolumab A Study of Nivolumab by Itself or Nivolumab Combined With Ipilimumab in Patients With Advanced or Metastatic Solid Tumors Active, not recruiting
NCT01966445 Phase I GSK2849330 Dose Escalation Study to Investigate the Safety, Pharmacokinetics, and Pharmacodynamics of GSK2849330 in Subjects With Advanced Her3-Positive Solid Tumors Completed
NCT01968109 Phase I Nivolumab + Relatlimab Relatlimab Safety Study of Anti-LAG-3 With and Without Anti-PD-1 in the Treatment of Solid Tumors Recruiting
NCT01976741 Phase I Rogaratinib Phase I Dose Escalation Pan-FGFR (Fibroblast Growth Factor Receptor) Inhibitor Completed
NCT02030067 Phase Ib/II RX-3117 Dose-Finding and Safety Study for Oral Single-Agent to Treat Advanced Malignancies Completed
NCT02043665 Phase I Coxsackievirus A21 Systemic Treatment Of Resistant Metastatic Disease Employing CVA21 and Pembrolizumab in Non-small Cell Lung Cancer and Bladder Cancer (STORM/ KEYNOTE-200) (STORM) Completed
NCT02091141 Phase II Erlotinib Alectinib Cobimetinib + Vemurafenib Pertuzumab + Trastuzumab Vismodegib Atezolizumab My Pathway: A Study Evaluating Herceptin/Perjeta, Tarceva, Zelboraf/Cotellic, Erivedge, Alecensa, and Tecentriq Treatment Targeted Against Certain Molecular Alterations in Participants With Advanced Solid Tumors Active, not recruiting
NCT02177695 Phase II Cisplatin + Gemcitabine Aldoxorubicin + Cisplatin + Filgrastim + Methotrexate + Vinblastine S1314, Co-expression Extrapolation (COXEN) Program to Predict Chemotherapy Response in Patients With Bladder Cancer Active, not recruiting
NCT02323191 Phase I Atezolizumab + Emactuzumab A Study of Emactuzumab and Atezolizumab Administered in Combination in Participants With Advanced Solid Tumors Active, not recruiting
NCT02346955 Phase I CM-24 CM-24 + Pembrolizumab Study of CM-24 (MK-6018) Alone and In Combination With Pembrolizumab (MK-3475) in Participants With Selected Advanced or Recurrent Malignancies (MK-6018-001) Terminated
NCT02351739 Phase II Pembrolizumab Acalabrutinib Study of the Combination of ACP-196 and Pembrolizumab in Subjects With Platinum-refractory Metastatic Bladder Cancer Completed
NCT02360618 Phase II Metformin + Simvastatin Metformin and Simvastatin Use in Bladder Cancer Unknown status
NCT02365818 Phase II CG0070 Safety and Efficacy of CG0070 Oncolytic Virus Regimen for High Grade Non-Muscle Invasive Bladder Cancer After BCG Failure Completed
NCT02452424 Phase Ib/II Pembrolizumab + Pexidartinib A Combination Clinical Study of PLX3397 and Pembrolizumab To Treat Advanced Melanoma and Other Solid Tumors Terminated
NCT02528357 Phase I GSK3174998 Pembrolizumab GSK3174998 Alone or With Pembrolizumab in Subjects With Advanced Solid Tumors Completed
NCT02529553 Phase I LY3076226 A Study of LY3076226 in Participants With Advanced or Metastatic Cancer Completed
NCT02543645 Phase Ib/II Atezolizumab + Varlilumab A Study of Varlilumab and Atezolizumab in Patients With Advanced Cancer Terminated
NCT02554812 Phase Ib/II Avelumab + PF-04518600 Avelumab + PD 0360324 Avelumab + Utomilumab Avelumab + PF-04518600 + Utomilumab A Study Of Avelumab In Combination With Other Cancer Immunotherapies In Advanced Malignancies (JAVELIN Medley) Recruiting
NCT02605863 Phase II Enzalutamide Enzalutamide for Bladder Cancer Chemoprevention Terminated
NCT02643303 Phase Ib/II Durvalumab + Poly ICLC Tremelimumab A Phase 1/2 Study of In Situ Vaccination With Tremelimumab and IV Durvalumab Plus PolyICLC in Subjects With Advanced, Measurable, Biopsy-accessible Cancers Recruiting
NCT02646319 Phase I Nab-Rapamycin Nanoparticle Albumin-Bound Rapamycin in Treating Patients With Advanced Cancer With mTOR Mutations Completed
NCT02675829 Phase II Ado-trastuzumab emtansine Trial of Ado-Trastuzumab Emtansine for Patients With HER2 Amplified or Mutant Cancers Active, not recruiting
NCT02753309 Phase 0 Sirolimus A Study of Rapamycin Combined With Intravesical BCG in Patients With Non-muscle Invasive Bladder Cancer Active, not recruiting
NCT02808143 Phase I BCG solution + Pembrolizumab Pembrolizumab and BCG Solution in Treating Patients With Recurrent Non-Muscle-Invasive Bladder Cancer Recruiting
NCT02880371 Phase Ib/II ARRY-382 + Pembrolizumab A Study of ARRY-382 in Combination With Pembrolizumab for the Treatment of Patients With Advanced Solid Tumors Completed
NCT02952248 Phase I BI 754091 A Trial to Find and Investigate a Safe Dose of a New Substance (BI 754091) for Patients With Solid Tumours Active, not recruiting
NCT03023319 Phase I Bosutinib + Pemetrexed Disodium Bosutinib in Combination With Pemetrexed in Patients With Selected Metastatic Solid Tumors Recruiting
NCT03224182 Phase III Apaziquone A Study of Intravesical Qapzola (Apaziquone) as a Surgical Adjuvant in Patients Undergoing TURBT Active, not recruiting
NCT03294304 Phase II Cisplatin + Gemcitabine + Nivolumab Nivolumab, Gemcitabine, and Cisplatin in Treatment of Bladder Cancer (MIBC) Undergoing Cystectomy Active, not recruiting
NCT03298958 Phase III Sirolimus Secondary Prevention Trial of Rapamycin in Patients With Resected Non-muscle Invasive Bladder Cancer Withdrawn
NCT03319745 Phase II Pembrolizumab A Window of Opportunity Study of Pembrolizumab in Patients With Bladder Cancer Undergoing Radical Cystectomy Active, not recruiting
NCT03330561 Phase I PRS-343 PRS-343 in HER2-Positive Solid Tumors Recruiting
NCT03333616 Phase II Ipilimumab + Nivolumab Nivolumab Combined With Ipilimumab for Patients With Advanced Rare Genitourinary Tumors Recruiting
NCT03454451 Phase I CPI-006 CPI-006 + Pembrolizumab CPI-006 + CPI-444 CPI-006 Alone and in Combination With CPI-444 and With Pembrolizumab for Patients With Advanced Cancers Recruiting
NCT03519256 Phase II BMS-986205 + Nivolumab Nivolumab BCG solution + Nivolumab BCG solution + BMS-986205 + Nivolumab A Study of Nivolumab or Nivolumab Plus Experimental Medication BMS-986205 With or Without Bacillus Calumette-Guerin (BCG) in BCG Unresponsive Bladder Cancer That Has Not Invaded Into the Muscle Wall of the Bladder (CheckMate 9UT) Recruiting
NCT03568539 Phase Ib/II Sintilimab IBI308 in Subjects With Advanced/Metastatic Solid Malignancies Active, not recruiting
NCT03596372 Phase I BAY1834942 Study of BAY1834942 in Patients With Solid Tumors Active, not recruiting
NCT03628677 Phase I AB154 AB154 + GLS-010 A Study to Evaluate the Safety and Tolerability of AB154 in Participants With Advanced Malignancies Recruiting
NCT03629756 Phase I AB928 + GLS-010 A Study to Evaluate the Safety and Tolerability of Immunotherapy Combinations in Participants With Advanced Malignancies Recruiting
NCT03637803 Phase I MRx0518 + Pembrolizumab MRx0518 and Pembrolizumab Combination Study Recruiting
NCT03661320 Phase III Cisplatin + Gemcitabine + Nivolumab Cisplatin + Gemcitabine BMS-986205 + Cisplatin + Gemcitabine + Nivolumab A Study of Chemo Only Versus Chemo Plus Nivo With or Without BMS-986205, Followed by Post- Surgery Therapy With Nivo or Nivo and BMS-986205 in Patients With MIBC Recruiting
NCT03762161 Phase II trifluridine/tipiracil hydrochloride A Phase II Study of Lonsurf (TAS-102) in Metastatic Platinum and Checkpoint Inhibitor-resistant Bladder Cancer Recruiting
NCT03767348 Phase Ib/II Nivolumab + RP1 RP1 Study of RP1 Monotherapy and RP1 in Combination With Nivolumab Recruiting
NCT03775850 Phase Ib/II EDP1503 EDP1503 + Pembrolizumab A Study of EDP1503 in Patients With Colorectal Cancer, Breast Cancer, and Checkpoint Inhibitor Relapsed Tumors Recruiting
NCT03816345 Phase I Nivolumab Nivolumab in Treating Patients With Autoimmune Disorders or Advanced, Metastatic, or Unresectable Cancer Recruiting
NCT03872947 Phase I Pembrolizumab + TRK-950 Carboplatin + Gemcitabine + TRK-950 Imiquimod + TRK-950 Paclitaxel + Ramucirumab + TRK-950 Nivolumab + TRK-950 Cisplatin + Gemcitabine + TRK-950 Fluorouracil + Irinotecan + Leucovorin + TRK-950 A Study of TRK-950 in Combinations With Anti-Cancer Treatment Regimens in Patients With Advanced Solid Tumors Recruiting
NCT03892642 Phase Ib/II Avelumab + BCG solution Avelumab Plus Bacille Calmette-Guerin (BCG) in Patients With Non-muscle Invasive Bladder Cancer Recruiting
NCT04068896 Phase I NGM120 Study of NGM120 in Subjects With Advanced Solid Tumors and Pancreatic Cancer Using Combination Therapy Recruiting
NCT04134312 Phase I MVA-BN-Brachyury A Phase 1 Open Label Trial of Intravenous Administration of MVA-BN-Brachyury Vaccine in Patients With Advanced Cancer Recruiting
NCT04145622 Phase Ib/II DS-7300a Study of DS-7300a in Participants With Advanced Solid Malignant Tumors Recruiting
NCT04152499 Phase Ib/II SKB264 Phase I-II, FIH, TROP2 ADC, Advanced Unresectable/Metastatic Solid Tumors, Refractory to Standard Therapies (A264) Recruiting
NCT04179162 Phase Ib/II BCG solution + Gemcitabine Bacillus Calmette-Guerin (BCG) and Gemcitabine in People With High-Grade Non-Muscle Invasive Bladder Cancer That Came Back After BCG Treatment Recruiting
NCT04209114 Phase III Nivolumab + NKTR-214 Nivolumab A Study of Nivolumab Plus NKTR-214 vs Nivolumab Alone vs Standard of Care in Participants With Bladder Cancer That Has Invaded the Muscle Wall of the Bladder and Who Cannot Get Cisplatin, a Type of Medicine Given to Treat Bladder Cancer. Recruiting
NCT04241185 Phase III Pembrolizumab Cisplatin Mitomycin C Gemcitabine Fluorouracil Efficacy and Safety of Pembrolizumab (MK-3475) in Combination With Chemoradiotherapy (CRT) Versus CRT Alone in Muscle-invasive Bladder Cancer (MIBC) (MK-3475-992/KEYNOTE-992) Recruiting
NCT04250597 Phase I GNX102 Study of GNX102 in Patients With Advanced Solid Tumors Recruiting
NCT04260802 Phase Ib/II OC-001 + unspecified PD-L1 antibody OC-001 + unspecified PD-1 antibody OC-001 A Study to Evaluate the Safety and Pharmacokinetics of OC-001 in Patients With Locally Advanced or Metastatic Cancers Not yet recruiting
NCT04344795 Phase I TPST-1495 Pembrolizumab + TPST-1495 Phase 1a/1b Study of TPST-1495 Alone and With Pembrolizumab in Subjects With Solid Tumors Recruiting
NCT04383743 Phase Ib/II Cisplatin + Doxorubicin + Methotrexate + Pegfilgrastim + Pembrolizumab + Vinblastine Pembrolizumab and Combination Chemotherapy Before Surgery for the Treatment of Muscle-Invasive Bladder Cancer Not yet recruiting
NCT04389632 Phase I SGN-B6A A Study of SGN-B6A in Advanced Solid Tumors Recruiting
NCT04482309 Phase II Trastuzumab deruxtecan A Phase 2 Study of T-DXd in Patients With Selected HER2 Expressing Tumors (DPT02) Not yet recruiting