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Molecular Profile | ERBB3 V104M |
Therapy | Alpelisib |
Indication/Tumor Type | urinary bladder cancer |
Response Type | sensitive |
Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
---|---|---|---|---|---|---|---|
ERBB3 V104M | urinary bladder cancer | sensitive | Alpelisib | Preclinical - Cell culture | Actionable | In a preclinical study, Piqray (alpelisib) treatment inhibited proliferation of a bladder cancer cell line harboring ERBB3 (HER3) V104M in culture (PMID: 38751013). | 38751013 |
PubMed Id | Reference Title | Details |
---|---|---|
(38751013) | HER3 V104 mutations regulate cell signaling, growth, and drug sensitivity in cancer. | Full reference... |