Profile Response Detail


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Molecular Profile PIK3CA E542Q PIK3CA E674Q
Therapy Alpelisib + Nintedanib
Indication/Tumor Type urinary bladder cancer
Response Type sensitive


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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
PIK3CA E542Q PIK3CA E674Q urinary bladder cancer sensitive Alpelisib + Nintedanib Preclinical - Cell line xenograft Actionable In a preclinical study, combination treatment with Ofev (nintedanib) and Piqray (alpelisib) led to synergistic inhibition of growth in bladder cancer cell lines harboring PIK3CA E542Q and PIK3CA E674Q in culture, and led to inhibition of tumor growth in a cell line xenograft model (PMID: 36805958). 36805958
PubMed Id Reference Title Details
(36805958) Tumor and Stromal Cell Targeting with Nintedanib and Alpelisib Overcomes Intrinsic Bladder Cancer Resistance. Full reference...