Therapy Detail

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Therapy Name CG0070
Synonyms
Therapy Description

CG0070 is a recombinant adenovirus that selectively infects, replicates and produces GM-CSF in tumor cells, which leads to tumor lysis and cytotoxic T cell-mediated tumor cell death (PMID: 16397056).

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Drug Name Trade Name Synonyms Drug Classes Drug Description
CG0070 Oncolytic adenovirus encoding GM-CSF CG0070 is a recombinant adenovirus that selectively infects, replicates and produces GM-CSF in tumor cells, which leads to tumor lysis and cytotoxic T cell-mediated tumor cell death (PMID: 16397056, PMID: 28755959).

Filtering

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  • Simple literal full or partial string matches
  • Separate multiple filter terms with a spaces, order doesn't matter (a b c and c b a are equivalent )
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  • Use quotes to match a longer phrase which contains spaces "mtor c1483f"

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
Unknown unknown urinary bladder cancer not applicable CG0070 Phase II Actionable In a Phase II trial, treatment with CG0070 resulted in a complete response rate of 47% (21/45) in patients with BGC-unresponsive high grade non-muscle invasive bladder cancer (PMID: 28755959; NCT02365818). 28755959

Filtering

  • Case insensitive filtering will display rows where any text in any cell matches the filter term
  • Simple literal full or partial string matches
  • Separate multiple filter terms with a spaces, order doesn't matter (a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page, filtering has no impact on query parameters
  • Use quotes to match a longer phrase which contains spaces "mtor c1483f"

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  • Generally, the default sort order for tables is set to be first column ascending, however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column, be sure to set ascending or descending order for a given column, before moving on to the next column.

Clinical Trial Phase Therapies Title Recruitment Status
NCT02365818 Phase II CG0070 Safety and Efficacy of CG0070 Oncolytic Virus Regimen for High Grade Non-Muscle Invasive Bladder Cancer After BCG Failure Completed
NCT01438112 Phase II Valrubicin Mitomycin C CG0070 Interferon gamma Gemcitabine Efficacy Study of Recombinant Adenovirus for Non Muscle Invasive Bladder Cancer (BOND) Terminated


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