Profile Response Detail


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Molecular Profile HRAS G12V
Therapy Binimetinib + Everolimus
Indication/Tumor Type urinary bladder cancer
Response Type sensitive


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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
HRAS G12V urinary bladder cancer sensitive Binimetinib + Everolimus Preclinical - Cell culture Actionable In a preclinical study, the combination of Binimetinib (MEK162) and Afinitor (everolimus) reduced phosphorylation of ERK and S6 and worked synergistically to inhibit growth of a bladder cell line harboring HRAS G12V in culture (PMID: 26544513). 26544513
PubMed Id Reference Title Details
(26544513) Mutant HRAS as novel target for MEK and mTOR inhibitors. Full reference...