Therapy Detail

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Therapy Name 3D185
Synonyms
Therapy Description

3D185 inhibits FGFR1/2/3 and CSF-1R, which potentially inhibits Fgfr signaling, modulates the tumor microenvironment, and inhibits tumor growth (PMID: 31438996).

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Drug Name Trade Name Synonyms Drug Classes Drug Description
3D185 3D-185|3D 185|HH185 CSF1R Inhibitor 28 FGFR1 Inhibitor 28 FGFR2 Inhibitor 23 FGFR3 Inhibitor 19 3D185 inhibits FGFR1/2/3 and CSF-1R, which potentially inhibits Fgfr signaling, modulates the tumor microenvironment, and inhibits tumor growth (PMID: 31438996).

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
FGFR3 fusion FGFR3 mut multiple myeloma sensitive 3D185 Preclinical - Cell culture Actionable In a preclinical study, 3D185 inhibited proliferation of a multiple myeloma cell line harboring an FGFR3 fusion and an FGFR3 mutation in culture (PMID: 31438996). 31438996
FGFR3 S249C urinary bladder cancer sensitive 3D185 Preclinical - Cell culture Actionable In a preclinical study, 3D185 inhibited downstream signaling and proliferation in a bladder cancer cell line harboring FGFR3 S249C in culture (PMID: 31438996). 31438996
FGFR3 amp urinary bladder cancer sensitive 3D185 Preclinical - Cell culture Actionable In a preclinical study, 3D185 inhibited proliferation of a bladder cancer cell line harboring FGFR3 amplification in culture (PMID: 31438996). 31438996
FGFR2 amp stomach cancer sensitive 3D185 Preclinical - Cell line xenograft Actionable In a preclinical study, 3D185 inhibited downstream signaling and proliferation of gastric cancer cell lines harboring FGFR2 amplification in culture and induced dose-dependent tumor growth inhibition in a cell line xenograft model (PMID: 31438996). 31438996
FGFR2 N549H Advanced Solid Tumor predicted - sensitive 3D185 Preclinical - Biochemical Actionable In a preclinical study, 3D185 inhibited the kinase activity of FGFR2 N549H in an in vitro assay (PMID: 31438996). 31438996
FGFR1 V561M Advanced Solid Tumor predicted - sensitive 3D185 Preclinical - Biochemical Actionable In a preclinical study, 3D185 inhibited kinase activity of FGFR1 V561M in an in vitro assay (PMID: 31438996). 31438996
FGFR2 amp colorectal cancer sensitive 3D185 Preclinical - Cell culture Actionable In a preclinical study, 3D185 inhibited proliferation of a colorectal cancer cell line harboring FGFR2 amplification in culture (PMID: 31438996). 31438996
FGFR1 amp lung cancer sensitive 3D185 Preclinical - Cell line xenograft Actionable In a preclinical study, 3D185 inhibited downstream signaling and proliferation of a lung cancer cell line harboring FGFR1 amplification in culture and inhibited signaling and induced dose-dependent tumor growth inhibition in a cell line xenograft model (PMID: 31438996). 31438996
FGFR2 amp triple-receptor negative breast cancer sensitive 3D185 Preclinical - Cell culture Actionable In a preclinical study, 3D185 inhibited proliferation of a triple-negative breast cancer cell line harboring FGFR2 amplification in culture (PMID: 31438996). 31438996

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Clinical Trial Phase Therapies Title Recruitment Status Covered Countries Other Countries


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