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|Drug Name||Trade Name||Synonyms||Drug Classes||Drug Description|
|S-49076||S49076||Aurkb Inhibitors 20 AXL Inhibitor 27 FGFR1 Inhibitor 23 FGFR2 Inhibitor 16 FGFR3 Inhibitor 13 MET Inhibitor 51||S-49076 is a multi-kinase inhibitor that inhibits wild-type and mutant forms of MET and FGFR1-2, as well as FGFR3, AXL, MER, and AURKB, resulting in decreased downstream signaling, and potentially resulting in decreased tumor growth (PMID: 23804704, PMID: 28624695, PMID: 28619752).|
|Molecular Profile||Indication/Tumor Type||Response Type||Therapy Name||Approval Status||Evidence Type||Efficacy Evidence||References|
|Unknown unknown||Advanced Solid Tumor||not applicable||S-49076||Phase I||Actionable||In a Phase I trial, S-49076 demonstrated safety and limited preliminary clinical activity in patients with advanced solid tumors, resulting in stable disease as best response in 50% of patients, with 23% demonstrating stable disease for at least 3 months, and 9 patients demonstrating stable disease for at least 6 months (PMID: 28624695).||28624695|
|FGFR2 act mut||stomach carcinoma||sensitive||S-49076||Preclinical - Cell line xenograft||Actionable||In a preclinical study, S-49076 inhibited Met activation, resulting in growth inhibition of gastric carcinoma cells harboring FGFR2 activating mutations in culture and in cell line xenograft models (PMID: 23804704).||23804704|
|FGFR3 act mut||urinary bladder cancer||predicted - sensitive||S-49076||Preclinical||Actionable||In a preclinical study, S-49076 inhibited autophosphorylation of FGFR3 and downstream signaling in bladder cancer cells over expressing constitutively active FGFR3 in culture (PMID: 23804704).||23804704|
|FGFR3 - TACC3||urinary bladder cancer||predicted - sensitive||S-49076||Preclinical||Actionable||In a preclinical study, S-49076 inhibited autophosphorylation of FGFR3 and downstream signaling in bladder cancer cells that have been demonstrated to harbor FGFR3-TACC3 in culture (PMID: 23804704, PMID: 23175443).||23175443 23804704|
|Clinical Trial||Phase||Therapies||Title||Recruitment Status|