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Ref Type
Authors Filip Janku, Gopa Iyer, Anna Spreafico, Noboru Yamamoto, Yung-Jue Bang, Elena Elez, Maja J. De Jonge, Harry J.M. Groen, Frederik Marmé, Kathrin Gollmer, Annie St-Pierre, Maritza Melendez, Anna Mais, Heidi Nauwelaerts, Uz M. Stammberger, Reinhard Dummer
Title A phase I study of LXH254 in patients (pts) with advanced solid tumors harboring MAPK pathway alterations.
Abstract Text J Clin Oncol 36, no. 15_suppl (May 20 2018) 2586-2586


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Molecular Profile Treatment Approach
Gene Name Source Synonyms Protein Domains Gene Description Gene Role
Therapy Name Drugs Efficacy Evidence Clinical Trials
Drug Name Trade Name Synonyms Drug Classes Drug Description
Gene Variant Impact Protein Effect Variant Description Associated with drug Resistance
Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
BRAF mutant Advanced Solid Tumor predicted - sensitive LXH 254 Case Reports/Case Series Actionable In a Phase I trial, LXH 254 treatment resulted in partial response in 2.6% (2/75) and stable disease in 33% (25/75) of patients with advanced solid tumors harboring MAPK pathway alterations, one of the patient achieved partial response harbored a BRAF mutation (J Clin Oncol 36, no. 15_suppl (May 20 2018) 2586-2586; NCT02607813). detail...