Therapy Detail

Therapy Name DS-1205c + Osimertinib
Synonym
Therapy Description

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Drug Name Trade Name Synonyms Drug Classes Drug Description
DS-1205c AXL Inhibitor 24 DS-1205c is a small molecule inhibitor of Axl, which may have anti-tumor activity (J Thorac Oncol. 2017 Nov, 12(11): S2289-S2290, abstract P3.04-012).
Osimertinib Tagrisso AZD9291 EGFR Inhibitor 3rd gen 16 Tagrisso (osimertinib) is a third-generation EGFR inhibitor that selectively binds mutant forms of the EGF receptor, inhibiting downstream signaling and potentially reducing cell proliferation and growth in EGFR overexpressing tumors (PMID: 29151359). Tagrisso (osimertinib) is FDA-approved for use in patients with non-small cell lung cancer harboring EGFR exon 19 deletions, L858R, or T790M (FDA.gov).
Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
Clinical Trial Phase Therapies Title Recruitment Status
NCT03255083 Phase I DS-1205c + Osimertinib DS-1205c With Osimertinib for Metastatic or Unresectable Epidermal Growth Factor Receptor (EGFR)-Mutant Non-Small Cell Lung Cancer Recruiting