Therapy Detail

Therapy Name DS-1205c + Osimertinib
Therapy Description

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Drug Name Trade Name Synonyms Drug Classes Drug Description
DS-1205c AXL Inhibitor 24 DS-1205c is a small molecule inhibitor of Axl, which may have anti-tumor activity (J Thorac Oncol. 2017 Nov, 12(11): S2289-S2290, abstract P3.04-012).
Osimertinib Tagrisso AZD9291 EGFR Inhibitor 3rd gen 15 Tagrisso (osimertinib) is a third-generation EGFR inhibitor that selectively binds mutant forms of the EGF receptor, inhibiting downstream signaling and potentially reducing cell proliferation and growth in EGFR overexpressing tumors (NCI Drug Dictionary). Tagrisso (osimertinib) is FDA-approved for use in patients with non-small cell lung cancer harboring EGFR exon 19 deletions, L858R, or T790M (FDA.gov).
Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
Clinical Trial Phase Therapies Title Recruitment Status
NCT03255083 Phase I DS-1205c + Osimertinib DS-1205c With Osimertinib for Metastatic or Unresectable Epidermal Growth Factor Receptor (EGFR)-Mutant Non-Small Cell Lung Cancer Recruiting