Therapy Detail

Therapy Name Goserelin + MK2206
Synonym
Therapy Description

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Drug Name Trade Name Synonyms Drug Classes Drug Description
Goserelin Zoladex Goserelin acetate Zoladex (goserelin) is a synthetic analog of lutenizing hormone-releasing hormone, which causes decreased testosterone production in males and decreased estradiol production in females (NCI Drug Dictionary). Zoladex (goserelin) is FDA approved for use in prostate carcinoma (FDA.gov).
MK2206 MK-2206 Akt Inhibitor (Pan) 17 MK2206 binds to and inhibits the activity of AKT in a non-ATP competitive manner, which may result in the inhibition of the PI3K/AKT signaling pathway and tumor cell proliferation (PMID: 20571069).
Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
Clinical Trial Phase Therapies Title Recruitment Status
NCT01776008 Phase II Goserelin + MK2206 Akt Inhibitor MK-2206 and Anastrozole With or Without Goserelin Acetate in Treating Patients With Stage II-III Breast Cancer Terminated