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Drug Name LY3214996
Trade Name
Synonyms LY-3214996|LY 3214996
Drug Descriptions

LY3214996 inhibits ERK1/2, potentially resulting in decreased growth of tumors with alterations in the RAS/MAPK pathway (AACR; Cancer Res 2017;77(13 Suppl):Abstract nr 4973, PMID: 31744895).

DrugClasses ERK Inhibitor (pan) 15

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Therapy Name Drugs Efficacy Evidence Clinical Trials
Abemaciclib + LY3214996 Abemaciclib LY3214996 0 2
Gemcitabine + LY3214996 + Nab-paclitaxel Gemcitabine LY3214996 Nab-paclitaxel 0 1
Hydroxychloroquine + LY3214996 Hydroxychloroquine LY3214996 0 1
Ibrutinib + LY3214996 Ibrutinib LY3214996 0 1
LSN3074753 + LY3214996 LSN3074753 LY3214996 0 0
LY3009120 + LY3214996 LY3009120 LY3214996 0 0
LY3214996 LY3214996 0 3
LY3214996 + Midazolam LY3214996 Midazolam 0 1


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