Drug Detail

Contact

Missing content? – Request curation!

Request curation for specific Genes, Variants, or PubMed publications.

Have questions, comments, or suggestions? - Let us know!

Email us at : ckbsupport@jax.org

Drug Name LY3214996
Trade Name
Synonyms Temuterkib|LY-3214996|LY 3214996
Drug Descriptions

LY3214996 inhibits ERK1/2, potentially resulting in decreased growth of tumors with alterations in the RAS/MAPK pathway (AACR; Cancer Res 2017;77(13 Suppl):Abstract nr 4973, PMID: 31744895).

DrugClasses ERK Inhibitor (pan) 21
CAS Registry Number 1951483-29-6
NCIT ID C131335

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column. Be sure to set ascending or descending order for a given column before moving on to the next column.

Therapy Name Drugs Efficacy Evidence Clinical Trials
Abemaciclib + Cetuximab + LY3214996 Abemaciclib Cetuximab LY3214996 0 1
Abemaciclib + LY3214996 Abemaciclib LY3214996 1 3
Cetuximab + LY3214996 Cetuximab LY3214996 0 1
Gemcitabine + LY3214996 + Nab-paclitaxel Gemcitabine LY3214996 Nab-paclitaxel 0 1
Hydroxychloroquine + LY3214996 Hydroxychloroquine LY3214996 0 1
Ibrutinib + LY3214996 Ibrutinib LY3214996 0 1
LSN3074753 + LY3214996 LSN3074753 LY3214996 0 0
LY3009120 + LY3214996 LY3009120 LY3214996 3 0
LY3023414 + LY3214996 LY3023414 LY3214996 0 0
LY3214996 LY3214996 11 3
LY3214996 + LY3537982 LY3214996 LY3537982 0 1
LY3214996 + Midazolam LY3214996 Midazolam 0 1
LY3214996 + RMC-4550 LY3214996 RMC-4550 0 0
LY3214996 + RMC-4630 LY3214996 RMC-4630 0 1
LY3214996 + SCH772984 LY3214996 SCH772984 0 0
LY3214996 + Trametinib LY3214996 Trametinib 3 0


Additional content available in CKB BOOST