Drug Detail

Drug Name Cediranib
Trade Name
Synonyms AZD-2171|Recentin
Drug Descriptions

Cediranib (AZD-2171) is an ATP-competitive inhibitor of all three vascular endothelial growth factor receptors (FLT1, KDR, and FLT4) and KIT, thereby blocking VEGF-signaling, angiogenesis, and tumor cell growth (PMID: 15899831, PMID: 24714778).

DrugClasses KIT Inhibitor 50 VEGFR1 Inhibitor 4 VEGFR2 Inhibitor 34 VEGFR3 Inhibitor 5

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Therapy Name Drugs Efficacy Evidence Clinical Trials
Bevacizumab + Cediranib Bevacizumab Cediranib 1 0
Carboplatin + Cediranib Carboplatin Cediranib 1 0
Carboplatin + Cediranib + Paclitaxel Carboplatin Cediranib Paclitaxel 1 0
Cediranib Cediranib 18 4
Cediranib + Cisplatin + Gemcitabine Cediranib Cisplatin Gemcitabine 1 0
Cediranib + Cisplatin + Pemetrexed Cediranib Cisplatin Pemetrexed 0 1
Cediranib + Durvalumab Cediranib Durvalumab 1 2
Cediranib + Durvalumab + Olaparib Cediranib Durvalumab Olaparib 1 0
Cediranib + Gefitinib Cediranib Gefitinib 2 0
Cediranib + Lenalidomide Cediranib Lenalidomide 0 1
Cediranib + Lomustine Cediranib Lomustine 1 0
Cediranib + Olaparib Cediranib Olaparib 1 11
Cediranib + PLX4720 Cediranib PLX4720 1 0
Cediranib + PLX4720 + Selumetinib Cediranib PLX4720 Selumetinib 1 0
Cediranib + Saracatinib Cediranib Saracatinib 3 0


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