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Therapy Name | Gefitinib + TAK-701 |
Synonyms | |
Therapy Description | |
Drug Name | Trade Name | Synonyms | Drug Classes | Drug Description |
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Gefitinib | Iressa | ZD1839 | EGFR Inhibitor (Pan) 62 EGFR Inhibitor 1st gen 3 | Iressa (gefitinib) is a first-generation EGFR inhibitor that binds EGFR and inhibits downstream signaling, potentially resulting in decreased growth of tumors with EGFR activation (PMID: 26980062, PMID: 25302162, PMID: 15284455). Iressa (gefitinib) is FDA approved for use in patients with non-small cell lung cancer harboring an EGFR exon 19 deletion or EGFR L858R (FDA.gov). |
TAK-701 | HuL2G7 | HGF Antibody 4 | TAK-701 is a monoclonal antibody that targets HGF and prevents its binding to MET, resulting in decreased activation of HGF/MET signaling and potentially resulting in increased tumor cell death (PMID: 24019233). |
Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
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Clinical Trial | Phase | Therapies | Title | Recruitment Status | Covered Countries | Other Countries |
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