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Drug Name Dalantercept
Trade Name
Synonyms ACE-041|ALK1-Fc
Drug Descriptions

Dalantercept (ACE-041) is an ALK1 ligand trap composed of the ALK1 extracellular domain linked to the IgG Fc region, which binds to ALK1 ligands and prevents binding to the receptor, potentially leading to decreased tumor angiogenesis and growth and increased sensitivity to chemotherapeutic agents (PMID: 25708802, PMID: 26373572, PMID: 20124460, PMID: 30951193).

DrugClasses ALK Inhibitor 32
CAS Registry Number 1186210-24-1
NCIT ID C88296


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Therapy Name Drugs Efficacy Evidence Clinical Trials
Axitinib + Dalantercept Axitinib Dalantercept 0 1
Cisplatin + Dalantercept Cisplatin Dalantercept 2 0
Dalantercept Dalantercept 1 0
Dalantercept + Doxorubicin Dalantercept Doxorubicin 1 0
Dalantercept + Sorafenib Dalantercept Sorafenib 0 1

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