Drug Detail


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Drug Name Ipafricept
Trade Name
Synonyms Fzd8-Fc|OMP-54F28
Drug Descriptions

Ipafricept (OMP-54F28) is a fusion protein comprised of the ligand binding domain of the Frizzled family receptor 8 and the human immunoglobulin Fc domain, which binds Wnt and prevents downstream signaling, thereby inhibiting tumor growth (PMID: 25172549, PMID: 32694153, PMID: 31174889).

DrugClasses WNT Inhibitor 14
CAS Registry Number 1391727-24-4
NCIT ID C102565


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Therapy Name Drugs Efficacy Evidence Clinical Trials
Carboplatin + Ipafricept + Paclitaxel Carboplatin Ipafricept Paclitaxel 0 0
Gemcitabine + Ipafricept + Nab-paclitaxel Gemcitabine Ipafricept Nab-paclitaxel 0 0
Ipafricept Ipafricept 0 0
Ipafricept + Sorafenib Ipafricept Sorafenib 0 1

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