Drug Detail


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Drug Name DKN-01
Trade Name
Synonyms DKN 01|DKN01
Drug Descriptions

DKN-01 is a monoclonal antibody that binds to and inhibits Dkk1, a Wnt receptor antagonist, resulting in restoration of Wnt signaling and tumor growth inhibition (PMID: 28731148, PMID: 32192732).

DrugClasses WNT Inhibitor 15
CAS Registry Number NA
NCIT ID C113331


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Therapy Name Drugs Efficacy Evidence Clinical Trials
Atezolizumab + DKN-01 Atezolizumab DKN-01 0 1
Capecitabine + DKN-01 + Oxaliplatin + Tislelizumab Capecitabine DKN-01 Oxaliplatin Tislelizumab 0 1
DKN-01 DKN-01 0 3
DKN-01 + Docetaxel DKN-01 Docetaxel 0 1
DKN-01 + Fluorouracil + Irinotecan + Leucovorin DKN-01 Fluorouracil Irinotecan Leucovorin 0 1
DKN-01 + Nivolumab DKN-01 Nivolumab 0 1
DKN-01 + Paclitaxel DKN-01 Paclitaxel 0 2
DKN-01 + Pembrolizumab DKN-01 Pembrolizumab 0 1
DKN-01 + Sorafenib DKN-01 Sorafenib 0 0
DKN-01 + Tislelizumab DKN-01 Tislelizumab 0 1

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