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Drug Name CC-122
Trade Name
Synonyms Avadomide
Drug Descriptions

Avadomide (CC-122) is an immunomodulatory drug analog that targets Cereblon and promotes degradation of several proteins, including Ikaros and Aiolos, leading to decreased B-cell proliferation and decreased tumor angiogenesis (Blood Dec 2014, 124 (21) 3500).

DrugClasses

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Therapy Name Drugs Efficacy Evidence Clinical Trials
CC-122 CC-122 4 2
CC-122 + Cyclophosphamide + Prednisone + Rituximab + Vincristine Sulfate CC-122 Cyclophosphamide Prednisone Rituximab Vincristine Sulfate 0 1
CC-122 + Nivolumab CC-122 Nivolumab 0 2
CC-122 + Onatasertib CC-122 Onatasertib 0 1
CC-122 + Sorafenib CC-122 Sorafenib 0 1
CC-122 + Spebrutinib CC-122 Spebrutinib 0 1


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